Evidence map›Paper›PMID 33123676›Full record

ArticleJournal of cannabis research2020

Cannabis sativa extracts protect LDL from Cu

Bruno Musetti, Helena González-Ramos, Mercedes González, Edward M Bahnson, Javier Varela, Leonor Thomson

Open access · goldAbstract read
In one paragraph

Article in Journal of cannabis research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Bruno MusettiLaboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.
Helena González-RamosLaboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.
Mercedes GonzálezGrupo de Química Orgánica Medicinal, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.
Edward M BahnsonDivision of Vascular Surgery, Department of Surgery, and Department of Cell Biology & Physiology, Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Javier VarelaGrupo de Química Orgánica Medicinal, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.
Leonor ThomsonLaboratorio de Enzimología, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.
Universidad de la República de Uruguay · UYUniversity of North Carolina at Chapel Hill · US

Funding

Cell-Mediated Targeted Redox Intervention for the Treatment and Prevention of AtherosclerosisK01HL145354 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAHNSON, EDWARD M · 2020 to 2023
$528k
NHLBI NIH HHS K01 HL145354
6 · The paper itself

Abstract

backgroundMultiple therapeutic properties have been attributed to

objectivesThe primary objective of this study was to characterize the chemical profile and antioxidant properties of three varieties of

methodsFresh samples of female inflorescences from three stable

resultsThe main cannabinoids in the youngest inflorescences were tetrahydrocannabinolic acid (THC-A, 242 ± 62 mg/g) and tetrahydrocannabinol (THC, 7.3 ± 6.5 mg/g). Cannabinoid levels increased more than twice in two of the mature samples. A third sample showed a lower and constant concentration of THC-A and THC (177 ± 25 and 1 ± 1, respectively). The THC-A/THC rich cannabis extracts increased the latency phase of LDL oxidation by a factor of 1.2-3.5 per μg, and slowed down the propagation phase of lipoperoxidation (IC

conclusionCannabis whole extracts acted on both phases of lipid oxidation in copper challenged LDL. Those effects were just partially related with the content of cannabinoids and partially recapitulated by isolated pure cannabinoids. Our results support the potentially beneficial effects of cannabis sativa whole extracts on the initial phase of atherosclerosis.

Indexed as

atherosclerosisCannabis sativahemplow-density lipoproteinmaturationoxidationphytocannabinoids

Identifiers

PMID33123676
PMCPMC7592720
OpenAlexW3092744670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.