Evidence map›Paper›PMID 33123623›Full record

ArticlePlastic and aesthetic research2020

Inflammation as an orchestrator of cutaneous scar formation: a review of the literature.

Traci A Wilgus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and aesthetic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Extract ofFrontiers in pharmacology · 2026
    Article
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  7. Article
  8. Article
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  10. Article
  11. Article
  12. Fibrosis in burns: an overview of mechanisms and therapies.American journal of physiology. Cell physiology · 2023
    Review
  13. Review
  14. Review
  15. [Research advances on interleukin-6 in hypertrophic scar formation].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022
    Review
  16. Extracellular Vesicles in Facial Aesthetics: A Review.International journal of molecular sciences · 2022
    Review
  17. Review
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Traci A WilgusDepartment of Pathology, Ohio State University, Columbus, OH 43210, USA.

Funding

Evaluation of a novel pro-fibrotic regulatory pathway in the skinR21AR071115 · NIAMS · OHIO STATE UNIVERSITY · PI WILGUS, TRACI A · 2017 to 2018
$375k
NIAMS NIH HHS R21 AR071115
6 · The paper itself

Abstract

Inflammation is a key phase in the cutaneous wound repair process. The activation of inflammatory cells is critical for preventing infection in contaminated wounds and results in the release of an array of mediators, some of which stimulate the activity of keratinocytes, endothelial cells, and fibroblasts to aid in the repair process. However, there is an abundance of data suggesting that the strength of the inflammatory response early in the healing process correlates directly with the amount of scar tissue that will eventually form. This review will summarize the literature related to inflammation and cutaneous scar formation, highlight recent discoveries, and discuss potential treatment modalities that target inflammation to minimize scarring.

Indexed as

Inflammationmacrophagemast cellneutrophilscarskinwound healing

Identifiers

PMID33123623
PMCPMC7592345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.