Evidence map›Paper›PMID 33123613›Full record

ArticleOpen forum infectious diseases2020

Outcomes of Hepatitis C Virus Treatment in the New York City Jail Population: Successes and Challenges Facing Scale up of Care.

Justin Chan, Jessie Schwartz, Fatos Kaba, Angelica Bocour, Matthew J Akiyama, Laura Hobstetter, Zachary Rosner, Ann Winters, Patricia Yang, Ross MacDonald

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Justin ChanCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.ORCID 0000-0002-0056-8224
Jessie SchwartzBureau of Communicable Disease, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Fatos KabaCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.
Angelica BocourBureau of Communicable Disease, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Matthew J AkiyamaCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.
Laura HobstetterCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.
Zachary RosnerCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.
Ann WintersBureau of Communicable Disease, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Patricia YangCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.
Ross MacDonaldCorrectional Health Services, NYC Health + Hospitals, New York, New York, USA.
New York City Health and Hospitals Corporation · USNew York City Department of Health and Mental Hygiene · US

Funding

Advance Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants LivingR00DA043011 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI AKIYAMA, MATTHEW · 2020 to 2022
$747k
NIDA NIH HHS R00 DA043011
6 · The paper itself

Abstract

backgroundThe population detained in the New York City (NYC) jail system bears a high burden of hepatitis C virus (HCV) infection. Challenges to scaling up treatment include short and unpredictable lengths of stay. We report on the clinical outcomes of direct-acting antiviral (DAA) treatment delivered by NYC Health + Hospitals/Correctional Health Services in NYC jails from 2014 to 2017.

methodsWe performed a retrospective observational cohort study of HCV patients with detectable HCV ribonucleic acid treated with DAA therapy while in NYC jails. Some patients initiated treatment in jail, whereas others initiated treatment in the community and were later incarcerated. Our primary outcome was sustained virologic response at 12 weeks (SVR12).

resultsThere were 269 patients included in our cohort, with 181 (67%) initiating treatment in jail and 88 (33%) continuing treatment started in the community. The SVR12 virologic outcome data were available for 195 (72%) individuals. Of these, 172 (88%) achieved SVR12. Patients who completed treatment in jail were more likely to achieve SVR12 relative to those who were released on treatment (adjusted risk ratio, 2.93; 95% confidence interval, 1.35-6.34). Of those who achieved SVR12, 114 (66%) had a subsequent viral load checked. We detected recurrent viremia in 18 (16%) of these individuals, which corresponded to 10.6 cases per 100 person-years of follow-up.

conclusionsHepatitis C virus treatment with DAA therapy is effective in a jail environment. Future work should address challenges related to discharging patients while they are on treatment, loss to follow-up, and a high incidence of probable reinfection.

Indexed as

direct-acting antiviralhepatitis C virusincarceratedjailreinfection

Identifiers

PMID33123613
PMCPMC7580175
OpenAlexW3040491136

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.