Evidence map›Paper›PMID 33123608›Full record

ArticleOpen forum infectious diseases2020

Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1.

Beatriz Sierra, Ana B Pérez, Eglis Aguirre, Claudia Bracho, Odalys Valdés, Narciso Jimenez, Waldemar Baldoquin, Guelsys Gonzalez, Lilia M Ortega, Maria C Montalvo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. A20 as a Potential Therapeutic Target for COVID-19.Immunity, inflammation and disease · 2025
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  10. Article
  11. MCP-1: Function, regulation, and involvement in disease.International immunopharmacology · 2021
    Review
  12. Review
  13. Article
  14. COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Beatriz SierraCellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Ana B PérezCellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Eglis AguirreCellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Claudia BrachoCellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Odalys ValdésRespiratory Viruses Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Narciso JimenezMedical Attention Branch, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Waldemar BaldoquinEpidemiology Department Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Guelsys GonzalezRespiratory Viruses Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Lilia M OrtegaIntensive Care Unit, Medical Attention Branch, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Maria C MontalvoHepatitis Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Sonia ResikEnterovirus Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Delmis AlvarezDepartment of Computing, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Maria G GuzmánCenter for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Instituto de Medicina Tropical “Pedro Kourí” · CU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19's pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.

Indexed as

chemokinesCOVID-19cytokinesinflammationprognostic biomarkers

Identifiers

PMID33123608
PMCPMC7499702
OpenAlexW3082763671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.