Evidence map›Paper›PMID 33123603›Full record

ArticleJournal of immunology research2020

Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro.

Feng Tian, Qiang Lu, Jie Lei, Yunfeng Ni, Nianlin Xie, Daixing Zhong, Guang Yang, Shaokui Si, Tao Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. SIGIRR: An Orphan Receptor Mediating Anti-inflammatory Actions.Expert reviews in molecular medicine · 2025
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Feng TianDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Qiang LuDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Jie LeiDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Yunfeng NiDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Nianlin XieDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Daixing ZhongDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Guang YangDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Shaokui SiDepartment of Respiration, Third Hospital of Baoji, Baoji, China.
Tao JiangDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.ORCID https://orcid.org/0000-0002-5848-1922
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the effects of single immunoglobin IL-1 receptor-related protein (SIGIRR) on tumor necrosis factor- (TNF-) receptor-associated factor 6 (TRAF6) ubiquitination in acute lung injury (ALI) were evaluated in both alveolar epithelial cells and alveolar macrophage cells in vitro. Our results found that SIGIRR negatively regulated TRAF6 ubiquitination and such SIGIRR inhibition could enhance the TRAF6 expression in both alveolar epithelial cells (AECs) and alveolar macrophage cells (AMCs). SIGIRR knockdown may increase NF-

Indexed as

Acute Lung InjuryAlveolar Epithelial CellsCells, CulturedGene Expression RegulationGene Knockdown TechniquesHumansImmunity, InnateImmunomodulationInterleukin-8LipopolysaccharidesMacrophages, AlveolarNF-kappa BReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like Receptor 4Interleukin-8LipopolysaccharidesNF-kappa BReceptors, Interleukin-1SIGIRR protein, humanTNF Receptor-Associated Factor 6Toll-Like Receptor 4

Identifiers

PMID33123603
PMCPMC7584944
OpenAlexW3092652885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.