Evidence map›Paper›PMID 33123554›Full record

ArticleERJ open research2020

Nasal high-flow oxygen

Athanasia Papalampidou, Eleni Bibaki, Stylianos Boutlas, Ioannis Pantazopoulos, Nikolaos Athanasiou, Melanie Moylan, Vasileios Vlachakos, Vasileios Grigoropoulos, Konstantinos Eleftheriou, Zoe Daniil and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05829083 (Asymmetric), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05829083 narecruitingnot on this mapstarted 2023, after this paper: background citation

Asymmetric (DUET) Versus Conventional Nasal High Flow Interface for Management of Hypercapnic Patients With Mild to Moderate Acute Exacerbation of COPD: A Randomized, Crossover Clinical Trial

TypeinterventionalSponsorLarissa University HospitalRan2023 to 2025Enrolled50ConditionsCOPD Exacerbation, Hypercapnia, COPDArmsAsymmetric nasal cannula - DUET, Conventional nasal high flow cannula
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Athanasia PapalampidouFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Eleni BibakiRespiratory Dept, Venizelio General Hospital, Athens, Greece.
Stylianos BoutlasDept of Respiratory Medicine, School of Medicine, University of Thessaly, Larissa, Greece.
Ioannis PantazopoulosEmergency Dept, University Hospital of Larisa, Larissa, Greece.ORCID https://orcid.org/0000-0002-8846-519X
Nikolaos AthanasiouPulmonary Dept, Evangelismos Hospital, Athens, Greece.
Melanie MoylanDept of Epidemiology and Biostatistics, Auckland University of Technology, Auckland, New Zealand.
Vasileios VlachakosFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Vasileios GrigoropoulosFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Konstantinos EleftheriouFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Zoe DaniilDept of Respiratory Medicine, School of Medicine, University of Thessaly, Larissa, Greece.
Konstantinos GourgoulianisDept of Respiratory Medicine, School of Medicine, University of Thessaly, Larissa, Greece.
Ioannis KalomenidisFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Spyros ZakynthinosFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Eleni IschakiFirst Dept of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Evangelismos Hospital, Athens, Greece.
Evangelismos Hospital · GRUniversity of Thessaly · GRAuckland University of Technology · NZUniversity Hospital of Larissa · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoninvasive ventilation (NIV) is considered as the first-line treatment for acute exacerbation of COPD (AECOPD) complicated by respiratory acidosis. Recent studies demonstrate a role of nasal high-flow oxygen (NHF) in AECOPD as an alternative treatment in patients intolerant to NIV or with contraindications to it.

aimThe study aimed to evaluate whether NHF respiratory support is noninferior compared to NIV in respect to treatment failure, defined as need for intubation or change to alternative treatment group, in patients with AECOPD and mild-to-moderate acute or acute-on-chronic hypercapnic respiratory failure.

methodsWe designed a multicentre, prospective, randomised trial on patients with AECOPD, who have pH<7.35 but >7.25 and

conclusionGiven the increasing number of studies demonstrating the physiological effects of NHF in COPD patients, we hypothesise that NHF respiratory support will be noninferior to NIV in patients with AECOPD and mild-to-moderate acute or acute on chronic hypercapnic respiratory failure.

Identifiers

PMID33123554
PMCPMC7569159
OpenAlexW3093268340

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.