Evidence map›Paper›PMID 33123535›Full record

ArticleFrontiers in cell and developmental biology2020

Exosomes Derived From CircAkap7-Modified Adipose-Derived Mesenchymal Stem Cells Protect Against Cerebral Ischemic Injury.

Limin Xu, Haifeng Ji, Yufeng Jiang, Liying Cai, Xiaoyin Lai, Feifei Wu, Rongguo Hu, Xuelian Yang, Huan Bao, Mei Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  19. Andrographolide Suppresses Pyroptosis inOxidative medicine and cellular longevity · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Limin XuDepartment of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Haifeng JiDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Yufeng JiangDepartment of Clinical Medicine, Clinic Medical College of Anhui Medical University, Hefei, China.
Liying CaiDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Xiaoyin LaiDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Feifei WuDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Rongguo HuDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Xuelian YangDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Huan BaoDepartment of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Mei JiangDepartment of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Second Military Medical University · CNShanghai Pudong New Area Gongli Hospital · CNAnhui Medical University · CNShanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral ischemic injury is a complicated pathological process. Adipose-derived stromal cells (ADSCs) have been used as a therapeutic strategy, with their therapeutic effects chiefly attributed to paracrine action rather than

methodsTo explore whether exosomes derived from circAkap7-modified ADSCs (exo-circAkap7) have therapeutic effects on cerebral ischemic injury, a mouse model of tMCAO, as well as an

resultsResults showed that treatment with exo-circAkap7 protected against tMCAO in mice, and

conclusionWe demonstrate here that exo-circAkap7 protected against cerebral ischemic injury by promoting autophagy and ameliorating oxidative stress.

Indexed as

autophagycerebral ischemic injurycircular RNAexosomesoxidative stress

Identifiers

PMID33123535
PMCPMC7573549
OpenAlexW3090330339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.