Evidence map›Paper›PMID 33123230›Full record

ArticleExperimental and therapeutic medicine2020

Neuroendocrine syndrome in bronchial carcinoid tumors.

Cornel Savu, Alexandru Melinte, Joseph Lula Lukadi, Cristian Mirvald, Carmen Savu, Emil Belu, Camelia Diaconu, Laura Iliescu, Irina Balescu, Ovidiu Stiru and 3 more

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Neuroendocrine neoplasms of the lung: The latest updates.World journal of clinical oncology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cornel SavuDepartment of Thoracic Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Alexandru MelinteDepartment of Thoracic Surgery, 'Marius Nasta' National Institute of Pneumophtisiology, 050159 Bucharest, Romania.
Joseph Lula LukadiDepartment of Thoracic Surgery, 'Marius Nasta' National Institute of Pneumophtisiology, 050159 Bucharest, Romania.
Cristian MirvaldDepartment of Urology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.
Carmen SavuDepartment of Anesthesiology, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.
Emil BeluDepartment of Oncology, 'Prof. Dr. Al. Trestioreanu' Institute of Oncology, 022328 Bucharest, Romania.
Camelia DiaconuDepartment of Internal Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Laura IliescuDepartment of Internal Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Irina BalescuDepartment of Visceral Surgery, 'Ponderas' Academic Hospital, 021188 Bucharest, Romania.
Ovidiu StiruDepartment of Cardiac Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Ovidiu BratuDepartment of Urology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Gabriel GoreckiDepartment of Anaesthesia and Intensive Care, 'Ilfov' County Emergency Hospital, 022104 Bucharest, Romania.
Nicolae BacalbasaDepartment of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial carcinoid tumors in the Thoracic Surgery Clinic of the 'Marius Nasta' Institute of Pneumophtisiology between 2014 and 2018 were retrospectively reviewed. All patients were submitted to paraclinical tests, imagistic studies (computed tomography or magnetic resonance imaging), bronchoscopy and biopsy in order to have a positive diagnostic of pulmonary carcinoid. The most common clinical symptoms at the time of presentation were: Persistent cough followed by dyspnea and recurrent pulmonary infections. The main neuroendocrine syndromes found were Cushing and Carcinoid Syndrome. All patients were submitted to surgery with curative intent consisting of wedge resection (in 4 cases, 4.08%), lobectomy (in 79 cases, 80.61%), bilobectomy (in 5 cases, 5.1%) and pneumonectomy respectively (in 10 cases, 10.2%). In all cases neuroendocrine specific symptoms disappeared once the carcinoid tumor was removed. In conclusion, bronchial carcinoid tumors have a positive outcome in most cases. Specific neuroendocrine markers as well as neuroendocrine syndrome disappears once the tumor is removed.

Indexed as

bronchial tumorsbronchopulmonary neuroendocrine neoplasmscarcinoidneuroendocrine pulmonary tumorsneuroendocrine syndrome

Identifiers

PMID33123230
PMCPMC7588783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.