Evidence map›Paper›PMID 33123226›Full record

ReviewExperimental and therapeutic medicine2020

Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review).

Carmen Adella Sirbu, Raluca-Mihaela Mezei, Cristian Falup-Pecurariu, Ovidiu Gabriel Bratu, Anca Maria Sirbu, Minerva Claudia Ghinescu, Florentina Ionita Radu

Abstract readReview
In one paragraph

Review in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Nasal Mucociliary Clearance and Its Relationship With Disease Severity in Patients With Multiple Sclerosis.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  3. Article
  4. Inverse association between arterial stiffness and perceived fatigue independent of disability status and BMI in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carmen Adella SirbuDepartment of Preclinical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.
Raluca-Mihaela MezeiDepartment of Neurology, Central Military Emergency University Hospital, 010242 Bucharest, Romania.
Cristian Falup-PecurariuDepartment of Neurology, County Emergency Clinic Hospital, 500365 Brasov, Romania.
Ovidiu Gabriel BratuDepartment of Urology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Anca Maria SirbuDepartment of Endocrinology, 'C. I. Parhon' National Institute of Endocrinology, 011863 Bucharest, Romania.
Minerva Claudia GhinescuDepartment of Preclinical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.
Florentina Ionita RaduDepartment of Preclinical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis, demyelinating, inflammatory, degenerative, and chronic disease, raises many challenges in terms of disease management. The autonomic nervous system is affected by neuroinflammation but also contributes to its maintenance and the evolution of the disease. Multiple sclerosis interfering with parasympathetic or sympathetic modulation may influence the immune response. Less attention is paid to autonomic dysfunctions, although they produce a serious impact on the quality of life. In addition to motor disabilities, patients also have non-motor dysfunctions. Regardless of its clinical forms, patients with multiple sclerosis may have autonomous disturbances such as bladder, sexual, cardiovascular, thermoregulatory, gastrointestinal dysfunction and fatigue. These must be identified based on medical history, clinical symptoms, and specific paraclinical tests. In addition to the multitude of immunomodulatory therapeutic agents that influence the progression of the disease, the therapy of autonomic dysfunctions remains difficult to address. However, their identification and treatment lead to increased quality of patient management and avoid complications of this disease.

Indexed as

autonomic nervous systembladder dysfunctioncardiovascular dysfunctionfatiguegastrointestinal dysfunctionmultiple sclerosissexual dysfunctionthermoregulatory dysfunction

Identifiers

PMID33123226
PMCPMC7588778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.