ArticleEvidence-based complementary and alternative medicine : eCAM2020
Antioxidant Effect of Standardized Extract of Propolis (EPP-AF®) in Healthy Volunteers: A "Before and After" Clinical Study.
Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review.Nutrients · 2021Pooled it
- Artepillin C-rich propolis extract supplementation promotes muscle recovery following exercise-induced muscle damage in resistance-trained young females: a randomized, placebo-controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis.Toxins · 2024Trial
- Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Trial
- A propolis-rich hive environment affects redox gene expression and gut microbiota at the individual and social level in honey bees.FEMS microbes · 2026Article
- Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis.Phytotherapy research : PTR · 2025Review
- Bacterial cellulose doped with ZnO as a multifunctional bioactive platform for curcumin and propolis immobilization: synthesis, characterization, and wound healing potential.Microbial cell factories · 2025Article
- Effects of propolis extract supplementation in breeder and broiler diets and it's in ovo injection on immune status, blood parameters, vaccine-antibody response and intestinal microflora of broiler chick.Tropical animal health and production · 2025Article
- An Advanced Combinatorial System fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Oral Films Printed with Green Propolis Ethanolic Extract.Polymers · 2024Article
- New insights of propolis nanoformulation and its therapeutic potential in human diseases.ADMET & DMPK · 2024Review
- Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract.Molecules (Basel, Switzerland) · 2023Article
- Review on Propolis Applications in Food Preservation and Active Packaging.Plants (Basel, Switzerland) · 2023Review
- Antimicrobial Formulation of a Bacterial Nanocellulose/Propolis-Containing Photosensitizer for Biomedical Applications.Polymers · 2023Article
- Editorial: Therapeutic potential of propolis-fromFrontiers in pharmacology · 2023Article
- Leishmanicidal and immunomodulatory properties of Brazilian green propolis extract (EPP-AFFrontiers in pharmacology · 2023Article
- Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment.Pharmaceutics · 2022Article
- Propolis induces cardiac metabolism changes in 6-hydroxydopamine animal model: A dietary intervention as a potential cardioprotective approach in Parkinson's disease.Frontiers in pharmacology · 2022Article
- Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis.Antioxidants (Basel, Switzerland) · 2021Review
- Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages.Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPropolis is rich in polyphenols, especially flavonoids and phenolic acids, and has significant antioxidant activity, shown mainly in "
objectiveThe aim of this study was to evaluate the antioxidant efficacy and safety of a standardized propolis extract in healthy volunteers.
designA two-phase sequential, open-label, nonrandomized, before and after clinical trial.
methodsHealthy participants received two EPP-AF® doses (375 and 750 mg/d, P.O, tid) during 7 ± 2 days, starting with the lower doses. Immediately before starting EPP-AF® administration and at the end of each 7-day dosing schedule, blood and urine samples were collected for quantification of 8-OHDG (8-hydroxydeoxyguanosine) and 8-ISO (8-isoprostanes) in urine and GSH (reduced glutathione), GSSG (oxidized glutathione), SOD (superoxide dismutase), FRAP (Ferric Reducing Antioxidant Power), vitamin E, and MDA (malondialdehyde) in plasma.
resultsIn our study, we had 34 healthy participants (67.7% women, 30 ± 8 years old, 97% white). The 8-ISO, a biomarker of lipid peroxidation, decreased with both doses of EPP-AF® compared to baseline (8-ISO, 1.1 (0.9-1.3) versus 0.85 (0.75-0.95) and 0.89 (0.74-1.0), ng/mg creatinine,
conclusionEPP-AF® reduced biomarkers of oxidative stress cell damage in healthy humans, with increased antioxidant enzymatic capacity, especially of SOD. This trial is registered with the Brazilian Registry of Clinical Trials (ReBEC, RBR-9zmfs9).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.