Evidence map›Paper›PMID 33123136›Full record

ArticleFrontiers in immunology2020

Bacterial Lipoproteins Induce BAFF Production

Jintaek Im, Jung Eun Baik, Dongwook Lee, Ok-Jin Park, Dong Hyun Park, Cheol-Heui Yun, Seung Hyun Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026
    Review
  2. Review
  3. Immune Response Activation and Hepatoprotective Activity ofInternational journal of food science · 2025
    Article
  4. [Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  5. Frontiers in immunology · 2024
    Article
  6. Muramyl dipeptide potentiatesFrontiers in immunology · 2024
    Article
  7. Review
  8. Review
  9. Frontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jintaek ImDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Jung Eun BaikDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Dongwook LeeDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Ok-Jin ParkDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Dong Hyun ParkDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Cheol-Heui YunDepartment of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, South Korea.
Seung Hyun HanDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, South Korea.
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell activating factor (BAFF) plays a crucial role in survival, differentiation, and antibody secretion of B cells. Microbial products with B-cell mitogenic properties can indirectly promote expansion and activation of B cells by stimulating accessory cells, such as dendritic cells (DCs), to induce BAFF. Although bacterial lipoproteins are potent B-cell mitogen like lipopolysaccharides (LPSs), it is uncertain whether they can stimulate DCs to induce BAFF expression. Here, we evaluated the effect of bacterial lipoproteins on BAFF expression in mouse bone marrow-derived DCs. Lipoprotein-deficient

Indexed as

AnimalsB-Cell Activating FactorB-LymphocytesBone Marrow CellsCell ProliferationCulture Media, ConditionedDendritic CellsHEK293 CellsHumansLipopeptidesLipoproteinsMAP Kinase Signaling SystemMiceMice, Inbred C57BLMyeloid Differentiation Factor 88Staphylococcus aureusB-Cell Activating FactorCulture Media, ConditionedLipopeptidesLipoproteinsMyd88 protein, mouseMyeloid Differentiation Factor 88Pam2CSK4 lipopeptideTlr2 protein, mouseTnfsf13b protein, mouseToll-Like Receptor 2bacterial lipoproteinsB-cell activating factor (BAFF)bone marrow–derived dendritic cellsJNKMyD88Pam3CSK4TLR2/1

Identifiers

PMID33123136
PMCPMC7566273
OpenAlexW3089621179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.