Evidence map›Paper›PMID 33123119›Full record

ArticleFrontiers in immunology2020

Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients.

Elisa Cordero, Angel Bulnes-Ramos, Manuela Aguilar-Guisado, Francisca González Escribano, Israel Olivas, Julián Torre-Cisneros, Joan Gavaldá, Teresa Aydillo, Asunción Moreno, Miguel Montejo and 10 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

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  13. Positive flow cytometry crossmatch with discrepant antibody testing results following COVID-19 vaccination.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 1 country.

Elisa CorderoInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Angel Bulnes-RamosInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Manuela Aguilar-GuisadoInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Francisca González EscribanoServicio de Inmunología, Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Israel OlivasServicio de Inmunología, Instituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Julián Torre-CisnerosReina Sofia University Hospital, Maimonides Institute for Biomedical Research (IMIBIC), University of Córdoba (UCO), Córdoba, Spain.
Joan GavaldáVall d'Hebron University Hospital, VHIR, Barcelona, Spain.
Teresa AydilloInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Asunción MorenoUniversity Hospital Clinic, Barcelona, Spain.
Miguel MontejoCruces University Hospital, Bilbao, Spain.
María Carmen FariñasUniversity Hospital Marqués de Valdecilla, Santander, Spain.
Jordi CarrataláBelltvitge University Hospital, IDIBELL, University of Barcelona, Barcelona, Spain.
Patricia MuñozDepartment of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Marino BlanesUniversity Hospital La Fe, Valencia, Spain.
Jesús FortúnUniversity Hospital Ramón y Cajal, Madrid, Spain.
Alejandro Suárez-BenjumeaUniversity Hospital Virgen Macarena, Seville, Spain.
Francisco López-MedranoUnit of Infectious Diseases, University Hospital 12 de Octubre, Madrid, Spain.
Cristina RocaInstituto de Biomedicina de Sevilla (IBIS), University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain.
Rosario LaraReina Sofia University Hospital, Maimonides Institute for Biomedical Research (IMIBIC), University of Córdoba (UCO), Córdoba, Spain.
Pilar Pérez-RomeroNational Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Universidad de Sevilla · ESInstituto de Biomedicina de Sevilla · ESInstituto Maimónides de Investigación Biomédica de Córdoba · ESCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESHospital Clínic de Barcelona · ESHospital de Cruces · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario Ramón y Cajal · ESHospital Universitario Virgen Macarena · ESInstitut d'Investigació Biomédica de Bellvitge · ESInstituto de Salud Carlos III · ESMarqués de Valdecilla University Hospital · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA Results: We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%; Conclusion: Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.

Indexed as

BiomarkersFemaleFlow CytometryGraft RejectionHistocompatibilityHistocompatibility TestingHLA AntigensHumansInfluenza VaccinesIsoantibodiesLongitudinal StudiesMaleMiddle AgedOrgan TransplantationProspective StudiesRisk AssessmentBiomarkersHLA AntigensInfluenza VaccinesIsoantibodiesalloreactivityanti-human leukocyte antigencytomegalovirusdonor specific antibodiesorgan rejection

Identifiers

PMID33123119
PMCPMC7574595
OpenAlexW3092303353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.