Evidence map›Paper›PMID 33123048›Full record

ArticleFrontiers in psychology2020

Reduced Environmental Stimulation in Anorexia Nervosa: An Early-Phase Clinical Trial.

Sahib S Khalsa, Scott E Moseman, Hung-Wen Yeh, Valerie Upshaw, Beth Persac, Eric Breese, Rachel C Lapidus, Sheridan Chappelle, Martin P Paulus, Justin S Feinstein

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02801084 nacompletednot on this map

Examining the Effects of Reduced Environmental Stimulation on Eating Disorders

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2016 to 2017Enrolled21ConditionsAnorexia NervosaArmsReduced environmental stimulation
NCT05977894 enrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Wellbeing Monitoring During Sequential Reduced Environmental Stimulation-Floatation

TypeobservationalSponsorMercy Health OhioRan2023 to 2026Enrolled50ConditionsBurnout, Professional, Negative Affect, Positive Affect, WellbeingArmsReduced Environmental Stimulation Therapy
NCT06332963 narecruitingnot on this mapstarted 2024, after this paper: background citation

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2024 to 2028Enrolled102ConditionsAnorexia Nervosa, Body Image Disturbance, InteroceptionArmsFloatation-REST, IFT, EFT
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. The micro-phenomenology of Floatation-REST.BMC complementary medicine and therapies · 2026
    Article
  7. Article
  8. Sensing the Self: The Role of the Insula and Interoception in Body Image.Current topics in behavioral neurosciences · 2025
    Review
  9. Article
  10. Article
  11. Interoception in Fear Learning and Posttraumatic Stress Disorder.Focus (American Psychiatric Publishing) · 2023
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sahib S KhalsaLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Scott E MosemanLaureate Eating Disorders Program, Tulsa, OK, United States.
Hung-Wen YehLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Valerie UpshawLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Beth PersacLaureate Eating Disorders Program, Tulsa, OK, United States.
Eric BreeseLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Rachel C LapidusLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Sheridan ChappelleLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Martin P PaulusLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Justin S FeinsteinLaureate Institute for Brain Research (LIBR), Tulsa, OK, United States.
Laureate Institute for Brain Research · USUniversity of Tulsa · USMercy Health System · US

Funding

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Maëlle Camille Marie Gueguen · 2017 to 2026
$23.7M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
Investigating Flotation-REST as a novel technique for reducing anxiety and depressionR34AT009889 · NCCIH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2018 to 2020
$728k
NCCIH NIH HHS R34 AT009889NIGMS NIH HHS P20 GM121312NIMH NIH HHS K23 MH112949
6 · The paper itself

Abstract

Reduced Environmental Stimulation Therapy (REST) alters the balance of sensory input to the nervous system by systematically attenuating sensory signals from visual, auditory, thermal, tactile, vestibular, and proprioceptive channels. Previous research from our group has shown that REST CLINICAL

trial registrationClinicalTrials.gov; Identifier: NCT02801084 (April 01, 2016).

Indexed as

body awarenessbody imageeating disorderfloatation therapyinteroceptioninteroceptive awarenessstress

Identifiers

PMID33123048
PMCPMC7573249
OpenAlexW3091931160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.