Evidence map›Paper›PMID 33122980›Full record

ArticleAdvanced functional materials2020

Inspired by nature: facile design of nanoclay-organic hydrogel bone sealant with multifunctional properties for robust bone regeneration.

Chung-Sung Lee, Hee Sook Hwang, Soyon Kim, Jiabing Fan, Tara Aghaloo, Min Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chung-Sung LeeDivision of Advanced Prosthodontics, University of California Los Angeles, CA 90095, USA.
Hee Sook HwangDivision of Advanced Prosthodontics, University of California Los Angeles, CA 90095, USA.
Soyon KimDivision of Advanced Prosthodontics, University of California Los Angeles, CA 90095, USA.
Jiabing FanDivision of Advanced Prosthodontics, University of California Los Angeles, CA 90095, USA.
Tara AghalooDivision of Diagnostic and Surgical Sciences, University of California Los Angeles, CA 90095, USA.
Min LeeDivision of Advanced Prosthodontics, University of California Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

Tribbles homolog 3 and BMP-2 induced bone formationR01DE027332 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tara L Aghaloo, Min Lee · 2018 to 2026
$2.7M
NIDCR NIH HHS R01 DE027332
6 · The paper itself

Abstract

Bone repair is a complex process involving the sophisticated interplay of osteogenic stem cells, extracellular matrix, and osteoinductive factors, and it is affected by bacterial toxins and oxidative stress. Inspired by the nature of plant-derived phytochemicals and inorganic-organic analogues of the bone extracellular matrix, we report herein the facile design of a nanoclay-organic hydrogel bone sealant (NoBS) that integrates multiple physico-chemical cues for bone regeneration into a single system. Assembly of phytochemical-modified organic chitosan and silica-rich inorganic nanoclay serves as highly biocompatible and osteoconductive extracellular matrix mimics. The decorated phytochemical exerts inherent bactericidal and antioxidant activities, and acts as an intermolecular networking precursor for gelation with injectable and self-healing capabilities. Moreover, the NoBS exerts osteoinductive effects mediated by the nanoclay, which regulates the Wnt/β-catenin pathway, along with the addition of osteoinductive signals, resulting in bone regeneration in a non-healing cranial defect. Engineering of this integrated bone graft substitute with multifunctional properties inspired by natural materials may suggest a promising and effective approach for creating a favorable microenvironment for optimal bone healing.

Indexed as

bone regenerationbone sealantnanoclay-organic compositeNature-inspired hydrogelphytochemical

Identifiers

PMID33122980
PMCPMC7591105
OpenAlexW3082646979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.