ArticleNature and science of sleep2020
Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid.
Article in Nature and science of sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Incidence and risk factors for postnatal mental health-related hospitalisation among Aboriginal and non-Aboriginal women giving birth in the Northern Territory.BMC pregnancy and childbirth · 2026Article
- Pilot trial of delayed versus immediate financial incentives for smoking cessation.Contemporary clinical trials communications · 2026Article
- Spatial analysis of the percentages of smokers, alcohol drinkers, social welfare expenditure and insomniacs in Japan.Scientific reports · 2025Article
- Prevalence and factors associated with poor sleep quality among patients with hypertension in a primary care clinic: A cross-sectional study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025Article
- Prevalence of sleep disorders and association with various occupations among Indian population aged ≥ 45 years: Insight from Longitudinal Ageing Study in India (LASI).Journal of family medicine and primary care · 2024Article
- Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia.Psychopharmacology · 2024Article
- The Interactions between Smoking and Sleep.Biomedicines · 2024Review
- Changes in metabolic hormones and trace elements in CSF in active smokers indicate oxidative damage to brain cells.Endocrine connections · 2024Article
- Skipping breakfast and its association with sociodemographic characteristics, night eating syndrome, and sleep quality among university students in Bangladesh.BMC nutrition · 2024Article
- Association of cigarette smoking with cerebrospinal fluid biomarkers of insulin sensitivity and neurodegeneration.Brain and behavior · 2024Article
- The association between nicotine dependence and sleep quality in patients referred to a smoking cessation outpatient clinic: A cross-sectional study.Tobacco induced diseases · 2024Article
- Investigating the Relationship Between Smoking Behavior and Global Brain Volume.Biological psychiatry global open science · 2024Article
- The positive impact of smoking on poor sleep quality is moderated by IGF1 levels in cerebrospinal fluid: a case-control study among Chinese adults.Frontiers in psychiatry · 2024Article
- Exposure to secondhand smoke is associated with poor sleep quality among non-smoking university students in Bangladesh: a cross-sectional survey.Scientific reports · 2023Article
- Tobacco use and incident sleep parameters among a rural ageing population in South Africa.Tobacco induced diseases · 2023Article
- Metal ions in cerebrospinal fluid: Associations with anxiety, depression, and insomnia among cigarette smokers.CNS neuroscience & therapeutics · 2022Article
- Article
- Deteriorated sleep quality and influencing factors among undergraduates in northern Guizhou, China.PeerJ · 2022Article
- Current Cigarette Smoking Is Associated With a High Seizure Frequency and Anxiety Symptoms in People With Epilepsy.Frontiers in neurology · 2022Article
- The relationship between poor sleep quality measured by the Pittsburgh Sleep Quality Index and smoking status according to sex and age: an analysis of the 2018 Korean Community Health Survey.Epidemiology and health · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. However, the relationship among cigarette smoking, sleep disturbance and neurotransmitters has never been investigated in human cerebrospinal fluid (CSF).
methodsA total of 159 Chinese male subjects (81 active smokers and 78 non-smokers) who would undergo lumbar puncture before the surgery of anterior cruciate ligament reconstruction were recruited and 5mL-CSF samples were collected incidentally. CSF levels of DA, DAT, 5-HT, and serotonin transporter were measured using radioimmunoassay and ELISA. Sociodemographic data and the Pittsburgh Sleep Quality Index (PSQI) scale were collected before surgery.
resultsPSQI global scores, SOL, and CSF DA levels were significantly higher in active smokers compared to non-smokers (2.00 [1.00-4.75] scores vs 4.00 [3.00-6.00] scores,
conclusionCigarette smoking was indeed associated with sleep disturbance, shown by prolonged SOL, higher DA levels and lower DAT levels in CSF of active smokers.
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