Evidence map›Paper›PMID 33122823›Full record

ArticleActa pharmacologica Sinica2021

Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors.

Ting-Ting Fu, Gao Tu, Meng Ping, Guo-Xun Zheng, Feng-Yuan Yang, Jing-Yi Yang, Yang Zhang, Xiao-Jun Yao, Wei-Wei Xue, Feng Zhu

Abstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Major bioactive metabolites derived fromFrontiers in pharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting-Ting FuSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Gao TuSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Meng PingSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Guo-Xun ZhengSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Feng-Yuan YangSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Jing-Yi YangSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Yang ZhangSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Xiao-Jun YaoState Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, China.
Wei-Wei XueSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China. xueww@cqu.edu.cn.
Feng ZhuSchool of Pharmaceutical Sciences, Collaborative Innovation Center for Brain Science and Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China. zhufeng@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group I metabotropic glutamate receptors (mGlu

Indexed as

Allosteric RegulationAllosteric SiteHeterocyclic CompoundsHumansHydrogen BondingHydrophobic and Hydrophilic InteractionsLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingReceptor, Metabotropic Glutamate 5Receptors, Metabotropic GlutamateThermodynamicsHeterocyclic CompoundsLigandsmetabotropic glutamate receptor type 1Receptor, Metabotropic Glutamate 5Receptors, Metabotropic Glutamatecomputational modelingdrug selectivitymetabotropic glutamate receptorsnegative allosteric modulatorspsychiatric and neurodegenerative disorders

Identifiers

PMID33122823
PMCPMC8285414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.