Evidence map›Paper›PMID 33122755›Full record

ArticleScientific reports2020

High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors.

Rebecca Ronsley, Shahrad Rod Rassekh, Adam Fleming, Brianna Empringham, William Jennings, Carol Portwine, Sarah Burrow, Shayna Zelcer, Donna L Johnston, Lehana Thabane and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
  2. iScience · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Rebecca RonsleyDivision of Hematology, Oncology and BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Shahrad Rod RassekhDivision of Hematology, Oncology and BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Adam FlemingDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Brianna EmpringhamDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
William JenningsDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Carol PortwineDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Sarah BurrowDivision of Pediatric Orthopedics, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Shayna ZelcerDivision of Pediatric Hematology Oncology, Children's Hospital, London Health Sciences Center, London, ON, Canada.
Donna L JohnstonDivision of Pediatric Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Lehana ThabaneDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
M Constantine SamaanDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada. samaanc@mcmaster.ca.
McMaster University · CAUniversity of British Columbia · CAChildren's Hospital of Eastern Ontario · CALondon Health Sciences Centre · CAMcMaster Children's Hospital · CASt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While children with brain tumors are surviving at record rates, survivors are at risk of cardiovascular disease and type 2 diabetes mellitus; these conditions may be driven by excess body fat. Adiponectin in an adipokine that is inversely associated with the fat mass, and has been linked to cardiometabolic risk stratification in the general population. However, adiponectin's profile and determinants in SCBT have not been established. We tested the hypothesis that high molecular weight (HMW) adiponectin levels, the more biologically active form of adiponectin, were associated with adiposity in SCBT similarly to non-cancer controls. Seventy-four SCBT (n = 32 female) and 126 controls (n = 59 female) who were 5-17 years old were included. Partial correlations and multivariable regression analyses assessed the relationship between HMW adiponectin and adiposity. HMW adiponectin was inversely associated with total and central adiposity (FM%: β - 0.21, 95% CI - 0.15, - 0.08; p value < 0.0001; WHR: β - 0.14, 95% CI - 0.02, - 0.01; p value < 0.0001 ;WHtR: β - 0.21, 95% CI - 0.05, - 0.03; p value < 0.0001). In conclusion, HMW adiponectin is inversely correlated with adiposity in SCBT. Adiponectin may serve as a biomarker of cardiometabolic risk and response to interventions to prevent and manage obesity and its comorbidities in SCBT.

Indexed as

AdipokinesAdiponectinAdipose TissueAdiposityAdolescentBiomarkers, TumorBrain NeoplasmsCancer SurvivorsCardiovascular DiseasesChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleMolecular WeightAdipokinesAdiponectinBiomarkers, Tumor

Identifiers

PMID33122755
PMCPMC7596561
OpenAlexW4234358868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.