ArticleScientific reports2020
The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Folic Acid Supplementation and Risk of Gestational Diabetes Mellitus: A Systematic Review of the Literature.International journal of molecular sciences · 2025Pooled it
- Impacts of maternal lipid and homocysteine levels on the risks of pregnancy complications and adverse outcomes in both singleton and twin pregnancies: a population-based observational cohort study.BMC pregnancy and childbirth · 2026Observational
- Sucralose Exposure During Pregnancy Elevates Gestational Diabetes Risk via Gut Microbiota-Metabolic Axis in Mice.Journal of diabetes research · 2026Article
- Elevated homocysteine levels are associated with increased diabetes risk in patients with hypertension: a multicenter longitudinal study.Frontiers in cardiovascular medicine · 2026Article
- Longitudinal assessment of maternal micronutrients (folate and vitamin BEuropean journal of clinical nutrition · 2025Article
- Article
- Threshold effect of atherogenic index of plasma on type 2 diabetes mellitus and modification by uric acid in normal-weight adults with hypertension.Frontiers in endocrinology · 2024Article
- Metabolic profiles associated with opioid use and opioid use disorder: a narrative review of the literature.Current addiction reports · 2023Article
- Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications.BMC public health · 2023Article
- Article
- Review
- The Relationship Between Folate, Vitamin B12 and Gestational Diabetes Mellitus With Proposed Mechanisms and Foetal Implications.Journal of family & reproductive health · 2021Review
- A Novel Review of Homocysteine and Pregnancy Complications.BioMed research international · 2021Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the correlation between plasma total homocysteine (tHcy) level and gestational diabetes mellitus (GDM) in a Chinese Han population. This case-control study included 350 GDM patients and 346 gestational week-matched normal glucose tolerance (NGT) pregnant women. Plasma tHcy and insulin levels were analyzed by HPLC and ELISA respectively. Logistic regression analysis was used to investigate the correlation between plasma tHcy level and risk of GDM. Women with GDM had a higher plasma tHcy level than NGT women (6.61 ± 1.32 vs. 6.17 ± 1.29 μmol/L, P = 0.001)). The GDM risk was 1.79 (OR = 1.79, 95% CI 1.18-2.72, P = 0.006) times higher in women whose plasma tHcy level was ≥ 7.29 μmol/L compared to women with plasma tHcy level < 5.75 μmol/L. Stratified analysis showed the GDM risk were much higher when HOMA-IR index ≥ 2 (OR = 5.42, 95% CI 2.51-11.74, P < 0.001), age ≥ 30 years (OR = 5.14, 95% CI 2.78-9.52, P < 0.001), or women with a family history of type 2 diabetes mellitus (T2DM) (OR = 4.13, 95% CI 1.78-9.56, P = 0.001). In the Chinese Han population, an elevated plasma tHcy level may increase the overall risk of GDM especially in women with a high HOMA-IR index, increasing age or with family history of T2DM.
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