ArticleScientific reports2020
Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case-control study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The Risk of Rheumatic Disorders Among Patients With Rhinosinusitis: A Systematic Review and Meta-Analysis.International forum of allergy & rhinology · 2025Pooled it
- Machine Learning-Based Predictive Modeling for the Development of Chronic Rhinosinusitis Using Longitudinal Health Records.International forum of allergy & rhinology · 2026Article
- Chronic Rhinosinusitis and Autoimmune Diseases: A Comprehensive Large Population-Based Analysis.Laryngoscope investigative otolaryngology · 2026Article
- Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency.Journal of inflammation research · 2026Review
- Scavenger receptors: key players in the immunological puzzle of lupus.Frontiers in lupus · 2025Article
- Rheumatoid Arthritis Aggravates Disease Severity and the Risk of Postoperative Recurrence in Chronic Rhinosinusitis.Journal of inflammation research · 2025Article
- Current Review of Comorbidities in Chronic Rhinosinusitis.Current allergy and asthma reports · 2024Review
- Association between sinusitis and incident rheumatic diseases: a population-based study.RMD open · 2024Article
- Paranasal sinus occupancy assessed from magnetic resonance images-associations with clinical indicators in patients with systemic lupus erythematosus.Rheumatology (Oxford, England) · 2024Article
- Rheumatoid Arthritis Exacerbates Eosinophilic Inflammation Contributing to Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps.Journal of asthma and allergy · 2024Article
- Genetic correlation between chronic sinusitis and autoimmune diseases.Frontiers in allergy · 2024Article
- The causal relationship between autoimmune diseases and rhinosinusitis, and the mediating role of inflammatory proteins: a Mendelian randomization study.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- CXCR5Frontiers in immunology · 2024Article
- Effect of Chronic Rhinosinusitis on the Risk of Development of Rheumatoid Arthritis.Allergy, asthma & immunology research · 2023Article
- Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.Nature communications · 2023Article
- The causal relationship between multiple autoimmune diseases and nasal polyps.Frontiers in immunology · 2023Article
- Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case-Control Study Using a National Health Screening Cohort.International journal of environmental research and public health · 2022Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence shows that chronic rhinosinusitis (CRS) is associated with prior presence of autoimmune diseases; however, large-scale population-based studies in the literature are limited. We conducted a population-based case-control study investigating the association between CRS and premorbid autoimmune diseases by using the National Health Insurance Research Database in Taiwan. The CRS group included adult patients newly diagnosed with CRS between 2001 and 2013. The date of diagnosis was defined as the index date. The comparison group included individuals without CRS, with 1:4 frequency matching for gender, age, and index year. Premorbid diseases were forward traced to 1996. Univariate and multivariate logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals. The CRS group consisted of 30,611 patients, and the comparison group consisted of 122,444 individuals. Patients with CRS had a higher significant association with premorbid autoimmune diseases (adjusted OR 1.39 [1.28-1.50]). Specifically, patients with CRS had a higher significant association with ankylosing spondylitis, polymyositis, psoriasis, rheumatoid arthritis, sicca syndrome, and systemic lupus erythematosus (adjusted OR 1.49 [1.34-1.67], 3.47 [1.12-10.8], 1.22 [1.04-1.43], 1.60 [1.31-1.96], 2.10 [1.63-2.72], and 1.69 [1.26-2.25]). In subgroup analysis, CRS with and without nasal polyps demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 1.34 [1.14-1.58] and 1.50 [1.38-1.62]). In addition, CRS with fungal and non-fungal infections also demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 2.02 [1.72-2.49] and 1.39 [1.28-1.51]). In conclusion, a significant association between CRS and premorbid autoimmune diseases has been identified. These underlying mechanisms need further investigation.
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