Evidence map›Paper›PMID 33122706›Full record

ArticleScientific reports2020

Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center.

Jia Huang, Le Zheng, Zhen Li, Shiying Hao, Fangfan Ye, Jun Chen, Hayley A Gans, Xiaoming Yao, Jiayu Liao, Song Wang and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  9. SARS-CoV-2 re-infection versus prolonged shedding: A case series.Influenza and other respiratory viruses · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 3 countries.

Jia HuangNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Le ZhengDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Zhen LiDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Shiying HaoDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Fangfan YeNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Jun ChenNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China. drchenjun@163.com.
Hayley A GansDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Xiaoming YaoTranslational Medicine Laboratory, West China Hospital, Sichuan University, Chengdu, China.
Jiayu LiaoDepartment of Bioengineering, University of California at Riverside, Riverside, CA, USA.
Song WangNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Manfei ZengNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Liping QiuNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Chunyang LiBiomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
John C WhitinDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Lu TianDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Henry ChubbDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Kuo-Yuan HwaDepartment of Medicine, The University of Hong Kong, Hong Kong, SAR, China.
Scott R CeresnakDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Wei ZhangBiomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
Ying LuDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Yvonne A MaldonadoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Doff B McElhinneyDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Karl G SylvesterDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Harvey J CohenDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Lei LiuNational Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
Xuefeng B LingDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA. bxling@stanford.edu.
Stanford University · USSouthern University of Science and Technology · CNSichuan University · CNLucile Packard Children's Hospital · USUniversity of California, Riverside · USUniversity of Hong Kong · HKWest China Hospital of Sichuan University · CN

Funding

National Natural Science Foundation of China 81501651Sanming Project of Medicine in Shenzhen SZSM201812065
6 · The paper itself

Abstract

Recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive detection in infected but recovered individuals has been reported. Patients who have recovered from coronavirus disease 2019 (COVID-19) could profoundly impact the health care system. We sought to define the kinetics and relevance of PCR-positive recurrence during recovery from acute COVID-19 to better understand risks for prolonged infectivity and reinfection. A series of 414 patients with confirmed SARS-Cov-2 infection, at The Second Affiliated Hospital of Southern University of Science and Technology in Shenzhen, China from January 11 to April 23, 2020. Statistical analyses were performed of the clinical, laboratory, radiologic image, medical treatment, and clinical course of admission/quarantine/readmission data, and a recurrence predictive algorithm was developed. 16.7% recovered patients with PCR positive recurring one to three times, despite being in strict quarantine. Younger patients with mild pulmonary respiratory syndrome had higher risk of PCR positivity recurrence. The recurrence prediction model had an area under the ROC curve of 0.786. This case series provides characteristics of patients with recurrent SARS-CoV-2 positivity. Use of a prediction algorithm may identify patients at high risk of recurrent SARS-CoV-2 positivity and help to establish protocols for health policy.

Indexed as

ChinaClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingHospitalizationHumansPandemicsPneumonia, ViralPolymerase Chain ReactionRecurrenceTreatment Outcome

Identifiers

PMID33122706
PMCPMC7596704
OpenAlexW3097408824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.