ArticleScientific reports2020
Delineating colorectal cancer distribution, interaction, and risk prediction by environmental risk factors and serum trace elements.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Association between mercury levels and colorectal cancer: a systematic review, meta-analysis.BMC gastroenterology · 2026Pooled it
- Copper in colorectal cancer patients: a systematic review and meta-analysis.Carcinogenesis · 2025Pooled it
- Pooled it
- Global impact of dietary risks on cancers: burdens across regions from 1990 to 2021 and the projection to 2035.Frontiers in nutrition · 2025Article
- Qualitative insights into ecobiosocial factors influencing colorectal cancer risk in Malaysia.Health psychology and behavioral medicine · 2025Article
- Leveraging Xenobiotic-Responsive Cancer Stemness in Cell Line-Based Tumoroids for Evaluating Chemoresistance: A Proof-of-Concept Study on Environmental Susceptibility.International journal of molecular sciences · 2024Article
- Trace elements in hair or fingernail and gastroesophageal cancers: results from a population-based case-control study.Journal of exposure science & environmental epidemiology · 2023Article
- The role of heavy metals in the development of colorectal cancer.BMC cancer · 2023Article
- The Contributions of Trace Elements on Molecular Subtype-Specific Colorectal Cancer.Journal of Cancer · 2023Article
- Geospatial Assessment of Pesticide Concentration in Ambient Air and Colorectal Cancer Incidence in Arkansas, 2013-2017.International journal of environmental research and public health · 2022Article
- Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study.Frontiers in nutrition · 2022Article
- An integrated mass spectrometry imaging and digital pathology workflow for objective detection of colorectal tumours by unique atomic signatures.Chemical science · 2021Article
- Development of digital health management systems in longitudinal study: The Malaysian cohort experience.Digital healthArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The burden of colorectal cancer (CRC) is increasing worldwide especially in developing countries. This phenomenon may be attributable to lifestyle, dietary and environmental risk factors. We aimed to determine the level of 25 trace elements, their interaction with environmental risk factors, and subsequently develop a risk prediction model for CRC (RPM CRC). For the discovery phase, we used a hospital-based case-control study (CRC and non-CRC patients) and in the validation phase we analysed pre-symptomatic samples of CRC patients from The Malaysian Cohort Biobank. Information on the environmental risk factors were obtained and level of 25 trace elements measured using the ICP-MS method. CRC patients had lower Zn and Se levels but higher Li, Be, Al, Co, Cu, As, Cd, Rb, Ba, Hg, Tl, and Pb levels compared to non-CRC patients. The positive interaction between red meat intake ≥ 50 g/day and Co ≥ 4.77 µg/L (AP 0.97; 95% CI 0.91, 1.03) doubled the risk of CRC. A panel of 24 trace elements can predict simultaneously and accurate of high, moderate, and low risk of CRC (accuracy 100%, AUC 1.00). This study provides a new input on possible roles for various trace elements in CRC as well as using a panel of trace elements as a screening approach to CRC.
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