ArticleScientific reports2020
Citronellal perception and transmission by Anopheles gambiae s.s. (Diptera: Culicidae) females.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil.Insect molecular biology · 2026Article
- Bioactivities and biosynthesis of monoterpene-based biopesticides: current state and perspectives.Microbial cell factories · 2026Review
- Triple-Olfactory Mechanism Synergy: Development of a Long-Lasting DEET-Botanical Composite Repellent AgainstInsects · 2026Article
- Do natural or synthetic excito-repellents work better? A study on coastal malaria vectorPeerJ · 2026Article
- NlugOBP1 in Nilaparvata lugens involved in the perception of repellent agent geraniol.Scientific reports · 2025Article
- HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.PLoS neglected tropical diseases · 2025Article
- Impact of plant monoterpenes on insect pest management and insect-associated microbes.Heliyon · 2024Review
- Biological activity of cinnamaldehyde, citronellal, geraniol and anacardic acid on Haemonchus contortus isolates susceptible and resistant to synthetic anthelmintics.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2023Article
- Natural Product Citronellal can Significantly Disturb Chitin Synthesis and Cell Wall Integrity inJournal of fungi (Basel, Switzerland) · 2022Article
- Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anopheles gambiae s.s. is a key vector of Plasmodium parasites. Repellents, which may be a promising alternative to pesticides used to control malaria mosquitoes. Although citronellal is a known mosquito repellent, its repellency characteristics are largely unknown. Determining the specific odorant-binding proteins (OBPs) and odorant receptors (ORs) that detect and transfer the citronellal molecule in A. gambiae s.s. will help to define the mode of action of this compound. In this research, we assessed the repellent activity of citronellal in A. gambiae s.s. using a Y-tube olfactory meter, screened candidate citronellal-binding OBPs and ORs using reverse molecular docking, clarified the binding properties of predicted proteins for citronellal using fluorescence competition binding assay. Results showed that citronellal had a dosage effect on repelling A. gambiae s.s.. The 50% repellent rate was determined to be 4.02 nmol. Results of simulated molecular docking showed that the only proteins that bound tightly with citronellal were AgamOBP4 and AgamORC7. Fluorescence competitive binding assays confirmed the simulations. This research determined that citronellal was captured by AgamOBP4 and transmitted to AgamORC7 in A. gambiae s.s.. Our study will be beneficial in the further understanding the repellent mechanism of citronellal against A. gambiae s.s..
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