ArticleScientific reports2020
Circadian misalignment increases mood vulnerability in simulated shift work.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Impact of a 12-week Worksite Exercise Training Intervention on Mental, Metabolic, Physical, Spiritual, and Occupational Well-being Among Acute Care Nurses: A Randomized, Controlled Mixed Methods Pilot Study
The Impact of the Years of Blindness on Sleep and Dreaming Processes and Possible Relationships With Spatial Abilities
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Systematic review of actigraphy measures associated with behavioral and psychological symptoms of dementia.Chronobiology international · 2025Pooled it
- Circadian realignment and depressed mood: A systematic review.Sleep medicine reviews · 2025Pooled it
- A systematic review and meta-analysis on light therapy for sleep disorders in shift workers.Scientific reports · 2025Pooled it
- Monitoring Daily Sleep, Mood, and Affect Using Digital Technologies and Wearables: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Efficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Trial
- Daytime eating prevents mood vulnerability in night work.Proceedings of the National Academy of Sciences of the United States of America · 2022Trial
- Surgeon Social Jet Lag and Patient Risk of Major Adverse Events.JAMA surgery · 2026Article
- Oscillatory network efficiency predicts mood and fatigue during sleep deprivation.Communications biology · 2026Article
- Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications.Brain sciences · 2026Review
- Autophagy and Neuropsychiatric Disorders: Unraveling Molecular Mechanisms and Signaling Pathways.CNS & neurological disorders drug targets · 2026Review
- Interventions to improve mental well-being and sleep in paramedics: A scoping review.PloS one · 2026Article
- The Impact of Time of Night on Affect and Affective State Type: A Simulated Nightshift Study.Journal of sleep research · 2025Article
- Chronotype and Mental Health: Are Late Sleepers More Vulnerable?Current psychiatry reports · 2025Review
- The intricate link between circadian rhythms and aging: can resetting our circadian clock hold the key to longevity?Biogerontology · 2025Review
- The roles of Cryptochrome-1: the circadian clock as a control point in cancer therapy.Journal of translational medicine · 2025Review
- Impaired Responses to In Vitro Lipopolysaccharide-Induced Stimulation After Long-Term, Rotating Shift Work.International journal of environmental research and public health · 2025Article
- Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats.Journal of neuroinflammation · 2025Article
- High risk, low rest: a new framework for monitoring sleep vulnerability in emergency medicine.Frontiers in public health · 2025Observational
- Impact of Circadian Rhythm Disturbance and Chronotype on Medical Students' Mental State.Basic and clinical neuroscience · 2025Article
- Circadian rhythm and aggressive behavior in community-dwelling schizophrenia patients testing a moderated mediation model.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Night shift work can associate with an increased risk for depression. As night workers experience a 'misalignment' between their circadian system and daily sleep-wake behaviors, with negative health consequences, we investigated whether exposure to circadian misalignment underpins mood vulnerability in simulated shift work. We performed randomized within-subject crossover laboratory studies in non-shift workers and shift workers. Simulated night shifts were used to induce a misalignment between the endogenous circadian pacemaker and sleep/wake cycles (circadian misalignment), while environmental conditions and food intake were controlled. Circadian misalignment adversely impacted emotional state, such that mood and well-being levels were significantly decreased throughout 4 days of continuous exposure to circadian misalignment in non-shift workers, as compared to when they were under circadian alignment (interaction of "circadian alignment condition" vs. "day", mood: p < 0.001; well-being: p < 0.001; adjusted p-values). Similarly, in shift workers, mood and well-being levels were significantly reduced throughout days of misalignment, as compared to circadian alignment (interaction of "circadian alignment condition" vs. "day", mood: p = 0.002; well-being: p = 0.002; adjusted p-values). Our findings indicate that circadian misalignment is an important biological component for mood vulnerability, and that individuals who engage in shift work are susceptible to its deleterious mood effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.