Evidence map›Paper›PMID 33122390›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Mechanosensory Signaling in Astrocytes.

Egor A Turovsky, Alice Braga, Yichao Yu, Noemi Esteras, Alla Korsak, Shefeeq M Theparambil, Anna Hadjihambi, Patrick S Hosford, Anja G Teschemacher, Nephtali Marina and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. COeLife · 2026
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  11. Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Egor A TurovskyCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Alice BragaDepartment of Neuroscience, Tufts Neuroscience Institute, Tufts University School of Medicine, Boston, Massachusetts 02111.
Yichao YuUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom.
Noemi EsterasDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom.
Alla KorsakCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Shefeeq M TheparambilCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Anna HadjihambiCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Patrick S HosfordCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Anja G TeschemacherPhysiology, Pharmacology, and Neuroscience, University of Bristol, Bristol BS8 1TD, United Kingdom.ORCID 0000-0002-5514-2669
Nephtali MarinaCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Mark F LythgoeUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, United Kingdom.
Philip G HaydonDepartment of Neuroscience, Tufts Neuroscience Institute, Tufts University School of Medicine, Boston, Massachusetts 02111.
Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, United Kingdom a.gourine@ucl.ac.uk.
University College London · GBTufts University · USNational Hospital for Neurology and Neurosurgery · GBUniversity of Bristol · GB

Funding

ASTROCYTE/NEURON SIGNALINGR01NS037585 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HAYDON, PHILIP G · 1998 to 2019
$4.5M
Astrocyte-derived lactate modulates orexinergic neuron activity and behaviorR01NS107315 · NINDS · TUFTS UNIVERSITY BOSTON · PI HAYDON, PHILIP G, KONG, DONG · 2018 to 2022
$2.0M
British Heart Foundation PG/18/8/33540NINDS NIH HHS R01 NS037585NINDS NIH HHS R01 NS107315Wellcome Trust 200893Wellcome Trust 200893/Z/16/Z
6 · The paper itself

Abstract

Mechanosensitivity is a well-known feature of astrocytes, however, its underlying mechanisms and functional significance remain unclear. There is evidence that astrocytes are acutely sensitive to decreases in cerebral perfusion pressure and may function as intracranial baroreceptors, tuned to monitor brain blood flow. This study investigated the mechanosensory signaling in brainstem astrocytes, as these cells reside alongside the cardiovascular control circuits and mediate increases in blood pressure and heart rate induced by falls in brain perfusion. It was found that mechanical stimulation-evoked Ca

Indexed as

Adenosine TriphosphateAnimalsAstrocytesBlood PressureBrain StemCalcium SignalingCerebrovascular CirculationConnexin 43FemaleHeart RateMaleMechanotransduction, CellularMiceMice, KnockoutPeptidesPhysical StimulationAdenosine TriphosphateConnexin 43Gap 26 peptidePeptidesReceptors, Purinergic P2Y1Trpv4 protein, ratTRPV Cation Channelsastrocytesbaroreceptorcardiovasculargliamechanosensorysympathetic

Identifiers

PMID33122390
PMCPMC7724146
OpenAlexW3095786855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.