Evidence map›Paper›PMID 33122300›Full record

ArticleHeart (British Cardiac Society)2021

Haemodynamic determinants of improved aerobic capacity after tricuspid valve surgery in Ebstein anomaly.

Alexander Egbe, William Miranda, Heidi Connolly, Joseph Dearani

Open access · greenAbstract read
In one paragraph

Article in Heart (British Cardiac Society), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  6. Temporal change in cardiac function and clinical indices in adults with valvular pulmonic stenosis.International journal of cardiology. Congenital heart disease · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexander EgbeCardiovascular Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA cegbe2001@yahoo.com.ORCID 0000-0002-8810-3631
William MirandaCardiovascular Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Heidi ConnollyCardiovascular Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Joseph DearaniCardiovascular Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Mayo Clinic · US

Funding

Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of FallotR01HL158517 · NHLBI · MAYO CLINIC ROCHESTER · PI EGBE, ALEXANDER · 2021 to 2025
$2.9M
Ventricular and Pulmonary Vascular Reserve after the Fontan OperationK23HL141448 · NHLBI · MAYO CLINIC ROCHESTER · PI EGBE, ALEXANDER · 2018 to 2021
$693k
NHLBI NIH HHS K23 HL141448NHLBI NIH HHS R01 HL158517
6 · The paper itself

Abstract

backgroundAlthough tricuspid valve surgery improves functional capacity in patients with Ebstein anomaly, it is not always associated with improvement in aerobic capacity. The purpose of this study was to identify the determinants of improved aerobic capacity after tricuspid valve surgery in adults with Ebstein anomaly with severe tricuspid regurgitation.

methodsRetrospective study of patients with severe tricuspid regurgitation due to Ebstein anomaly that had tricuspid valve surgery at Mayo Clinic Rochester (2000-2019) and had preoperative and postoperative cardiopulmonary exercise tests and echocardiograms. The patients were divided into aerobic capacity(+) and aerobic capacity(-) groups depending on whether they had postoperative improvement in %-predicted peak oxygen consumption (VO

resultsOf 76 patients with severe tricuspid regurgitation due to Ebstein anomaly, 28 (37%) and 48 (63%) were in aerobic capacity(+) and aerobic capacity(-) groups, respectively. The average improvement in peak VO

conclusionsOne-third of patients with severe tricuspid regurgitation due to Ebstein anomaly had postoperative improvement in aerobic capacity, and atrial function indices were the best predictors of postoperative improvement in aerobic capacity. These data provide new insight into the haemodynamic determinants of exercise capacity and lay the foundation for further studies to determine whether postoperative improvement in aerobic capacity translates to improved long-term survival, and whether timing of tricuspid valve surgery based on these echocardiographic indices will improve long-term outcomes.

Indexed as

Cardiac Surgical ProceduresEbstein AnomalyExercise TestExercise ToleranceHeart FailurePostoperative ComplicationsTricuspid ValveAdultAtrial FunctionEchocardiographyExerciseFemaleHemodynamicsHumansMalePrognosiscongenital heart disease surgery

Identifiers

PMID33122300
PMCPMC8257558
OpenAlexW3097102422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.