Evidence map›Paper›PMID 33122228›Full record

ReviewBMJ case reports2020

Azacitidine-induced pneumonitis and literature review.

Paul Nguyen, Jawarya Safdar, Abdelaziz Mohamed, Ayman Soubani

Open access · greenAbstract readCase ReportsReview
In one paragraph

Review in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paul NguyenDepartment of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA pnguye@med.wayne.edu.
Jawarya SafdarDepartment of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
Abdelaziz MohamedDepartment of Pulmonary Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
Ayman SoubaniDivision of Pulmonary Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
Wayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of azacitidine-induced pneumonitis which is a rare adverse drug reaction and reported in less than 0.1% of cases. Common side effects of azacitidine are weakness, nausea, vomiting, constipation, injection site reactions, insomnia, among others. Our patient received azacitidine to treat her acute myeloid leukaemia and began to develop shortness of breath which progressed to dyspnoea at rest after completing a 7-day course of azacitidine and venetoclax. Initial chest X-ray revealed severe airspace disease for which the patient began receiving broad spectrum antibiotics, antifungals and antivirals therapy. Although infectious workup revealed invasive aspergillosis she did not clinically and radiologically improve despite being on isavuconazole until high-dose glucocorticoids were initiated. This case illustrates the importance of recognising and understanding the potential side effects of azacitidine and other chemotherapy agents as some adverse drug reactions can be life-threatening.

Indexed as

AgedAzacitidineEnzyme InhibitorsFemaleHumansInvasive Fungal InfectionsLungPneumoniaRadiography, ThoracicTomography, X-Ray ComputedAzacitidineEnzyme Inhibitorschemotherapyinterstitial lung diseaseunwanted effects / adverse reactions

Identifiers

PMID33122228
PMCPMC7597485
OpenAlexW3097869648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.