Evidence map›Paper›PMID 33122208›Full record

ArticleAJNR. American journal of neuroradiology2021

Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations.

O Rapalino, A Weerasekera, S J Moum, K Eikermann-Haerter, B L Edlow, D Fischer, A Torrado-Carvajal, M L Loggia, S S Mukerji, P W Schaefer and 3 more

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

O RapalinoFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.) orapalino@mgh.harvard.edu.ORCID 0000-0002-5038-4183
A WeerasekeraFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0003-0446-7604
S J MoumAnn & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine (S.J.M.).ORCID 0000-0002-8282-2619
K Eikermann-HaerterFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0002-5059-6012
B L EdlowNeurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-7235-8456
D FischerNeurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8181-0643
A Torrado-CarvajalA.A. Martinos Center for Biomedical Imaging (A.W., A.T.-C., M.L.L., E.R.), Charlestown, Massachusetts.ORCID 0000-0002-1540-2809
M L LoggiaFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0002-8026-5265
S S MukerjiNeurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-5677-6954
P W SchaeferFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0002-4222-6134
R G GonzalezFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0002-0234-3897
M H LevFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0003-0236-7319
E-M RataiFrom the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).ORCID 0000-0001-9476-6207
MACOM (United States) · USHarvard University · USDr. M.G.R. Educational and Research Institute · INLurie Children's Hospital · USUniversidad Rey Juan Carlos · ES

Funding

Core NIBSP01AT009965 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2018 to 2023
$10.9M
Longitudinal Study of childhood fMRI markers prior to reading onsetR01HD065762 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GAAB, NADINE, GRANT, PATRICIA ELLEN · 2011 to 2021
$6.3M
Supplementary funding for U01NS104326 Clinical Trial Readiness for SCA1 and SCA3 (“READISCA”)U01NS104326 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ASHIZAWA, TETSUO, OZ, GULIN · 2018 to 2022
$6.1M
Imaging neuroglial mechanisms of neuropathic pain-opioid interaction in HIVR01DA047088 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO, RATAI, EVA-MARIA · 2018 to 2022
$4.3M
In-vivo imaging of spinal and brain glial activation in low back pain patientsR01NS095937 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2016 to 2020
$3.5M
Partnership for Magnetic Resonance Spectroscopy Biomarker Development-SupplementR01NS080816 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2015 to 2019
$3.2M
Impact of intimate partner violence-related mild traumatic brain injuries on neural, cognitive, and psychological health of womenR01NS112694 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VALERA, EVE M · 2019 to 2022
$2.6M
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatallyR01HD085813 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2016 to 2020
$2.3M
Identifying Early Failure to Anti-angiogenic Therapy in Recurrent GBMR01CA190901 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RATAI, EVA-MARIA · 2015 to 2018
$1.4M
Immune Activation, Cerebral Metabolic Activity and Depression in Treated HIV-InfectionK23MH115812 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MUKERJI, SHIBANI SHARON · 2018 to 2022
$926k
NCCIH NIH HHS P01 AT009965NCI NIH HHS R01 CA190901NICHD NIH HHS R01 HD065762NICHD NIH HHS R01 HD085813NIDA NIH HHS R01 DA047088NIMH NIH HHS K23 MH115812NINDS NIH HHS R01 NS080816NINDS NIH HHS R01 NS095937NINDS NIH HHS R01 NS112694NINDS NIH HHS U01 NS104326
6 · The paper itself

Abstract

Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.

Indexed as

AgedCOVID-19HumansLeukoencephalopathiesMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleSARS-CoV-2White Matter

Identifiers

PMID33122208
PMCPMC7814804
OpenAlexW3097662094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.