Evidence map›Paper›PMID 33122198›Full record

ArticleThe Journal of biological chemistry2020

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding.

Maria C Bewley, Lovely Gautam, Mashanipalya G Jagadeeshaprasad, D Channe Gowda, John M Flanagan

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. VAR2CSA-Mediated Host Defense Evasion ofFrontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maria C BewleyDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Lovely GautamDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Mashanipalya G JagadeeshaprasadDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
D Channe GowdaDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA. Electronic address: gowda@psu.edu.
John M FlanaganDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA. Electronic address: jflanagan@psu.edu.
Pennsylvania State University · US

Funding

Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Therapeutic targeting of malarial placental cytoadherenceR01AI104844 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GOWDA, CHANNE D · 2015 to 2019
$2.4M
NIAID NIH HHS R01 AI104844NIGMS NIH HHS P41 GM103311NIGMS NIH HHS P41 GM103622NIGMS NIH HHS P41 GM111244
6 · The paper itself

Abstract

VAR2CSA is the placental-malaria-specific member of the antigenically variant

Indexed as

Antigens, ProtozoanCrystallography, X-RayFemaleGlycosaminoglycansHumansModels, MolecularPlacentaPlasmodium falciparumPregnancyProtein BindingProtein ConformationProtein DomainsAntigens, ProtozoanGlycosaminoglycansVAR2CSA protein, Plasmodium falciparumcarbohydrate functionchondroitin 4-sulfateelectron microscopyelectron microscopy (EM)malariamass spectrometryplacental malariaPlasmodium falciparum erythrocyte protein 1protein structuresmall angle x-ray scatteringVAR2CSA

Identifiers

PMID33122198
PMCPMC7939466
OpenAlexW3096302776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.