Evidence map›Paper›PMID 33121973›Full record

ArticleExperimental eye research2021

Morphometric analysis of in vitro human crystalline lenses using digital shadow photogrammetry.

Ashik Mohamed, Heather A Durkee, Siobhan Williams, Fabrice Manns, Arthur Ho, Jean-Marie A Parel, Robert C Augusteyn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Ashik MohamedOphthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India; Brien Holden Vision Institute Limited, Sydney, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Heather A DurkeeOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
Siobhan WilliamsOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
Fabrice MannsBrien Holden Vision Institute Limited, Sydney, Australia; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
Arthur HoBrien Holden Vision Institute Limited, Sydney, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, Australia; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Jean-Marie A ParelBrien Holden Vision Institute Limited, Sydney, Australia; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
Robert C AugusteynBrien Holden Vision Institute Limited, Sydney, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, Australia; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: b.augusteyn@bhvi.org.
University of Miami · USL V Prasad Eye Institute · IN

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Optics of the Growing Crystalline LensR01EY021834 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MANNS, FABRICE · 2012 to 2016
$2.3M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY021834
6 · The paper itself

Abstract

There is a great need for accurate biometric data on human lenses. To meet this, a compact tabletop optical comparator, the minishadowgraph, was built for measuring isolated eye lens shape and dimensions while the lens was fully immersed in supporting medium. The instrument was based around a specially designed cell and an illumination system which permitted image recording in both sagittal and equatorial (coronal) directions. Data were acquired with a digital camera and analyzed using a specially written MATLAB program as well as by manual measurements in image analysis software. The possible effect of lens orientation and gravity on the dimensions was examined by measuring dimensions with anterior or posterior surfaces up and by measuring lenses with calipers after removal from the minishadowgraph cell. Dimensions, curvatures and shape factors were obtained for 134 fully accommodated lenses ranging in age from birth to 88 years postnatal. Of these, 41 were from donors aged under 20 years, ages which are generally of limited availability. Thickness and diameter showed the same age-related trends described in previous studies but, for the lenses measured in air, age-dependent differences were observed in thickness (-5 to 0%) and diameter (+5 to 0%), consistent with gravitational sag. Anterior and posterior radii of curvature of the central 3 or 6 mm, depending on lens diameter, increase with age, with the anterior increase greater than the posterior. The anterior surface shape of the neonatal lens is that of a prolate ellipse and the posterior, an oblate ellipse. Both surfaces become hyperbolic after age 20. The data presented here on dimensions, shape and sagging will be of great value in assessing age-related changes in the optical and mechanical performance of the lens. In particular, the comprehensive data set from donors aged under 20 years provides a unique and valuable insight to the changes in size and shape during the early dynamic growth period of the lens.

Indexed as

Accommodation, OcularAdolescentAdultAgedAged, 80 and overAgingBiometryChildChild, PreschoolFemaleHumansInfantInfant, NewbornLens, CrystallineMaleMiddle AgedConic shape factorsDimensionsGravitational sagHuman lensMinishadowgraphRadius of curvature

Identifiers

PMID33121973
PMCPMC7855983
OpenAlexW3097223308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.