Trial reportJournal of neuroengineering and rehabilitation2020
Wearable hip-assist robot modulates cortical activation during gait in stroke patients: a functional near-infrared spectroscopy study.
Trial report in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03048968 (The Effect of a Walking Assist Robot on Gait Function and Brain Activity in Stroke Patients and Elderly Adults), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of a Walking Assist Robot on Gait Function and Brain Activity in Stroke Patients and Elderly Adults
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review of functional near-infrared spectroscopy-based task paradigms in stroke rehabilitation.Frontiers in human neuroscience · 2025Pooled it
- Powered single hip joint exoskeletons for gait rehabilitation: a systematic review and Meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- Advancing stroke diagnosis and management through nuclear medicine: a systematic review of clinical trials.Frontiers in medicine · 2024Pooled it
- Brain activity during real-time walking and with walking interventions after stroke: a systematic review.Journal of neuroengineering and rehabilitation · 2021Pooled it
- Effects of unilateral lower limb exoskeleton robot on gait improvement and brain function in patients with chronic stroke: a randomized clinical trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Electromyography (EMG)-triggered transcutaneous spinal cord and hip stimulation for gait rehabilitation in persons with chronic stroke: a randomized, controlled trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Effectiveness of unilateral lower-limb exoskeleton robot on balance and gait recovery and neuroplasticity in patients with subacute stroke: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2024Trial
- Safety & efficacy of a robotic hip exoskeleton on outpatient stroke rehabilitation.Journal of neuroengineering and rehabilitation · 2024Trial
- Embedded Adaptive Admittance Control for a Modular Hip Exoskeleton Using Deep Learning-Based Gait-Phase Estimation.Sensors (Basel, Switzerland) · 2026Article
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Low-cost Devices for Stroke Rehabilitation: A Review of Approaches, Designs, and Evidence.Restorative neurology and neuroscience · 2026Review
- Article
- Effect and optimal exercise prescription of robot-assisted gait training on lower extremity motor function in stroke patients: a network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Better Understanding Rehabilitation of Motor Symptoms: Insights from the Use of Wearables.Pragmatic and observational research · 2025Review
- Multimodal closed-loop strategies for gait recovery after spinal cord injury and stroke via the integration of robotics and neuromodulation.Frontiers in neuroscience · 2025Review
- Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke.Journal of neuroengineering and rehabilitation · 2024Article
- Applications of Functional Near-Infrared Spectroscopy (fNIRS) Neuroimaging During Rehabilitation Following Stroke: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Altered cortical activation patterns in post-stroke patients during walking with two-channel functional electrical stimulation: a functional near-infrared spectroscopy observational study.Frontiers in neurology · 2024Article
- Alterations in learning-related cortical activation and functional connectivity by high-definition transcranial direct current stimulation after stroke: an fNIRS study.Frontiers in neuroscience · 2023Article
- Task-Related Hemodynamic Changes Induced by High-Definition Transcranial Direct Current Stimulation in Chronic Stroke Patients: An Uncontrolled Pilot fNIRS Study.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGait dysfunction is common in post-stroke patients as a result of impairment in cerebral gait mechanism. Powered robotic exoskeletons are promising tools to maximize neural recovery by delivering repetitive walking practice.
objectivesThe purpose of this study was to investigate the modulating effect of the Gait Enhancing and Motivating System-Hip (GEMS-H) on cortical activation during gait in patients with chronic stroke.
methodsTwenty chronic stroke patients performed treadmill walking at a self-selected speed either with assistance of GEMS-H (GEMS-H) or without assistance of GEMS-H (NoGEMS-H). Changes in oxygenated hemoglobin (oxyHb) concentration in the bilateral primary sensorimotor cortex (SMC), premotor cortices (PMC), supplemental motor areas (SMA), and prefrontal cortices (PFC) were recorded using functional near infrared spectroscopy.
resultsWalking with the GEMS-H promoted symmetrical SMC activation, with more activation in the affected hemisphere than in NoGEMS-H conditions. GEMS-H also decreased oxyHb concentration in the late phase over the ipsilesional SMC and bilateral SMA (P < 0.05).
conclusionsThe results of the present study reveal that the GEMS-H promoted more SMC activation and a balanced activation pattern that helped to restore gait function. Less activation in the late phase over SMC and SMA during gait with GEMS-H indicates that GEMS-H reduces the cortical participation of stroke gait by producing rhythmic hip flexion and extension movement and allows a more coordinate and efficient gait patterns. Trial registration NCT03048968. Registered 06 Feb 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.