SynthesisJournal of orthopaedic surgery and research2020
Disordered leptin and ghrelin bioactivity in adolescent idiopathic scoliosis (AIS): a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Incidence of vitamin D deficiency in adolescent idiopathic scoliosis: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Global evolution of adolescent idiopathic scoliosis research (1990-2025): a bibliometric and visualization analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Epidemiological survey of scoliosis screening in schools among 51,025 adolescents in Gannan Tibetan autonomous prefecture, Gansu Province, China.Frontiers in public health · 2026Article
- The Role of Adipokines in Spinal Disease: A Narrative Review.JOR spine · 2025Review
- Association between theGenes · 2024Article
- Current biomechanical theories on the etiopathogenesis of idiopathic scoliosis.Spine deformity · 2024Review
- Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Differences in Pubertal Curve Progression among Females with Adolescent Idiopathic Scoliosis Using Pregnenolone Therapy: A Retrospective Case-Controlled Series.Journal of clinical medicine · 2024Article
- The Role of Muscle Biomarkers in Adolescent Idiopathic Scoliosis.Journal of clinical medicine · 2023Review
- Interaction between Selected Adipokines and Musculoskeletal and Cardiovascular Systems: A Review of Current Knowledge.International journal of molecular sciences · 2023Review
- Metabolic Imbalances and Bone Remodeling Agents in Adolescent Idiopathic Scoliosis: A Study in Postmenarcheal Girls.International journal of molecular sciences · 2023Article
- An Assessment of the Relationship Between BMI and Children Undergoing Surgical Procedures: A Retrospective Study.Childhood obesity (Print) · 2023Article
- Identification of an increased lifetime risk of major adverse cardiovascular events in UK Biobank participants with scoliosis.Open heart · 2023Article
- Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review.BMC musculoskeletal disorders · 2023Article
- Circulatory Adipokines and Incretins in Adolescent Idiopathic Scoliosis: A Pilot Study.Children (Basel, Switzerland) · 2022Article
- Salivary Progesterone Levels in Female Patients with a History of Idiopathic Scoliosis: A Retrospective Cross-Sectional Study.Clinics and practice · 2022Article
- Is ghrelin a biomarker of early-onset scoliosis in children with Prader-Willi syndrome?Orphanet journal of rare diseases · 2021Article
- Low Body Mass Index Levels and Idiopathic Scoliosis in Korean Children: A Cross-Sectional Study.Children (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdolescents with scoliosis consistently demonstrate lower body weight, lean muscle mass, and bone mineral density than healthy adolescent counterparts. Recent studies have focused on understanding how leptin and ghrelin signaling may play a role in adolescent idiopathic scoliosis (AIS). In our current study, we aim to evaluate the serum levels of leptin, soluble leptin receptor (sOB-R), and ghrelin in AIS patients through systematic review and meta-analysis.
methodsWe conducted our systematic review by searching the keywords in online databases including PubMed, Embase, Cochrane, Elsevier, Springer, and Web of Science from the time of database inception to January 2020. Inclusion criteria were studies that measure leptin, soluble leptin receptor (sOB-R), and ghrelin levels in AIS patients. Selection of studies, assessment of study quality, and data extraction were performed by two reviewers independently. Then, data was analyzed to calculate the mean difference and 95% confidence interval (CI).
resultsSeven studies concerning leptin/sOB-R and three studies concerning ghrelin were qualified for meta-analysis (one study concerning both leptin and ghrelin). Serum leptin of patients with AIS were significantly lower when compared with healthy controls, with the weighted mean difference (WMD) of - 0.95 (95% CI - 1.43 to - 0.48, p < 0.0001) after reducing the heterogeneity using six studies for meta-analysis, while sOB-R and ghrelin level was significantly higher in AIS group when compared with control group, with the WMD of 2.64 (95% CI 1.60 to 3.67, p < 0.001) and 1.42 (95% CI 0.48 to 2.35, p = 0.003), respectively.
conclusionOur current meta-analysis showed that serum level of leptin in AIS patients was significantly lower when compared with control subjects, while serum sOB-R and ghrelin levels were significantly higher in AIS patients. More clinical studies are still required to further validate the predictive value of leptin or ghrelin for the curve progression for AIS patients.
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