Evidence map›Paper›PMID 33121496›Full record

ReviewJournal of nanobiotechnology2020

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment.

Gaofeng Liang, Haojie Wang, Hao Shi, Haitao Wang, Mengxi Zhu, Aihua Jing, Jinghua Li, Guangda Li

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Stimuli-Responsive Materials for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  9. Review
  10. SCN-IgG functionalized NaYFRSC advances · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Photon Upconversion of Defect-Bound Excitons in hBN-Encapsulated MoSThe journal of physical chemistry. C, Nanomaterials and interfaces · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gaofeng LiangMedical College, Henan University of Science and Technology, Luoyang, 471023, Henan, China. lgfeng990448@163.com.
Haojie WangMedical College, Henan University of Science and Technology, Luoyang, 471023, Henan, China.
Hao ShiSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471023, China.
Haitao WangSchool of Environmental Science and Engineering, Nankai University, Tianjin,, 300350, China.
Mengxi ZhuMedical College, Henan University of Science and Technology, Luoyang, 471023, Henan, China.
Aihua JingSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471023, China.
Jinghua LiSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471023, China.
Guangda LiSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471023, China.

Funding

Innovation Scientists and Technicians Troop Construction Projects of Henan Province CXTD2017071National Natural Science Foundation of China 81741147National Natural Science Foundation of China U1804193Science and Technology Department of Henan Province (CN) 192102310189
6 · The paper itself

Abstract

Multifunctional lanthanide-based upconversion nanoparticles (UCNPs), which feature efficiently convert low-energy photons into high-energy photons, have attracted considerable attention in the domain of materials science and biomedical applications. Due to their unique photophysical properties, including light-emitting stability, excellent upconversion luminescence efficiency, low autofluorescence, and high detection sensitivity, and high penetration depth in samples, UCNPs have been widely applied in biomedical applications, such as biosensing, imaging and theranostics. In this review, we briefly introduced the major components of UCNPs and the luminescence mechanism. Then, we compared several common design synthesis strategies and presented their advantages and disadvantages. Several examples of the functionalization of UCNPs were given. Next, we detailed their biological applications in bioimaging and disease treatment, particularly drug delivery and photodynamic therapy, including antibacterial photodynamic therapy. Finally, the future practical applications in materials science and biomedical fields, as well as the remaining challenges to UCNPs application, were described. This review provides useful practical information and insights for the research on and application of UCNPs in the field of cancer.

Indexed as

AnimalsAnti-Bacterial AgentsAntineoplastic AgentsBiocompatible MaterialsCombined Modality TherapyDrug CarriersGenetic TherapyHumansLanthanoid Series ElementsLuminescent AgentsMetal NanoparticlesNeoplasmsParticle SizePhotochemotherapyPhotosensitizing AgentsStructure-Activity RelationshipAnti-Bacterial AgentsAntineoplastic AgentsBiocompatible MaterialsDrug CarriersLanthanoid Series ElementsLuminescent AgentsPhotosensitizing AgentsaPDTBioimagingBiomedical applicationsDrug deliveryPDTUpconversion

Identifiers

PMID33121496
PMCPMC7596946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.