ArticleBMC plant biology2020
Transcriptomic and functional analyses reveal an antiviral role of autophagy during pepper mild mottle virus infection.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Tobamoviruses: Advances in Molecular Biology, Host Interactions and Integrated Disease Management.Biology · 2026Review
- Transcriptomic and metabolomic response of the Xunhua pepper landrace to BBWV2 infection in Qinghai Province, China.BMC plant biology · 2026Article
- An Immunochromatographic Test Strip and Its Application in Rapid Screening of Pepper Mild Mottle Virus.Biosensors · 2026Article
- Key regulatory genes in sugar beet's defense against curly top virus identified by network analysis and qRT-PCR.Biochemistry and biophysics reports · 2025Article
- A Tradeoff Between the Escape fromPlants (Basel, Switzerland) · 2025Article
- Transcriptome Analysis of Pepper Leaves in Response to Tomato Brown Rugose Fruit Virus Infection.Plants (Basel, Switzerland) · 2025Article
- Transcriptome analysis provides new insights into the resistance of pepper to Phytophthora capsici infection.BMC genomics · 2025Article
- ATG6 interacting with NPR1 increaseseLife · 2025Article
- A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication.Cellular and molecular life sciences : CMLS · 2025Article
- The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus.Frontiers in plant science · 2025Article
- Advancements in Green Nanoparticle Technology: Focusing on the Treatment of Clinical Phytopathogens.Biomolecules · 2024Review
- Transcriptome Analysis of Tomato Leaves Reveals Candidate Genes Responsive toInternational journal of molecular sciences · 2024Article
- Plant Immunity against Tobamoviruses.Viruses · 2024Review
- Effect of natural products on host cell autophagy induced by Influenza A virus infection.Frontiers in cellular and infection microbiology · 2024Review
- Transcriptome analysis of two pepper genotypes infected with pepper mild mottle virus.Frontiers in genetics · 2023Article
- Transcriptome analysis of two near-isogenic lines of bell pepper (Frontiers in genetics · 2023Article
- A novel strategy for improving watermelon resistance to cucumber green mottle mosaic virus by exogenous boron application.Molecular plant pathology · 2022Article
- Role of pepper mild mottle virus as a tracking tool for fecal pollution in aquatic environments.Archives of microbiology · 2022Review
- Linking Autophagy to Potential Agronomic Trait Improvement in Crops.International journal of molecular sciences · 2022Review
- Effects of the Noncoding Subgenomic RNA of Red Clover Necrotic Mosaic Virus in Virus Infection.Journal of virology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPepper mild mottle virus (PMMoV) is a member in the genus Tobamovirus and infects mainly solanaceous plants. However, the mechanism of virus-host interactions remains unclear. To explore the responses of pepper plants to PMMoV infection, we analyzed the transcriptomic changes in pepper plants after PMMoV infection using a high-throughput RNA sequencing approach and explored the roles of host autophagy in regulating PMMoV infection.
resultsA total of 197 differentially expressed genes (DEGs) were obtained after PMMoV infection, including 172 significantly up-regulated genes and 25 down-regulated genes. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that most up-regulated DEGs were involved in plant abiotic and biotic stresses. Further analyses showed the expressions of multiple autophagy-related genes (ATGs) were increased after PMMoV infection in pepper and Nicotiana benthamiana plants. Through confocal microscopy and transmission electron microscopy, we have found that PMMoV infection in plant can induce autophagy, evidenced by the increased number of GFP-ATG8a fluorescent punctate and the appearance of double membrane autophagic structures in cells of N. benthamiana. Additionally, inhibition of autophagy significantly increased PMMoV RNA accumulation and aggravated systemic PMMoV symptoms through autophagy inhibitor (3-MA and E64d) treatment and silencing of NbATG expressions by a Tobacco rattle virus-induced gene silencing assays. These results indicated that autophagy played a positive role in plant resistance to PMMoV infection.
conclusionsTaken together, our results provide a transcriptomic insight into pepper responding to PMMoV infection and reveal that autophagy induced by PMMoV infection has an antiviral role in regulating PMMoV infection. These results also help us to better understand the mechanism controlling PMMoV infection in plants and to develop better strategies for breeding projects for virus-resistant crops.
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