Evidence map›Paper›PMID 33121356›Full record

ArticleAutophagy2020

BECN2 (beclin 2)-mediated non-canonical autophagy in innate immune signaling and tumor development.

Motao Zhu, Guangtong Deng, Changsheng Xing, Guangjun Nie, Rong-Fu Wang

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. [Dihydromyricetin reduces lipid accumulation in LO2 cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Motao ZhuDepartment of Medicine, And Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA.ORCID 0000-0002-6619-0412
Guangtong DengGeneral Surgery Department, Xiangya Hospital, Central South University , Changsha, Hunan, China.
Changsheng XingDepartment of Medicine, And Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA.
Guangjun NieCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China , Beijing, China.
Rong-Fu WangDepartment of Medicine, And Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA.
University of Southern California · USCentral South University · CNNational Center for Nanoscience and Technology · CN

Funding

Transport Oncophysics CoreU54CA210181 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WANG, RONGFU · 2016 to 2020
$9.3M
Novel Strategies for Intervention of Inflammatory Diseases and Cancer - Research Supplement to R01-CA101795R01CA101795 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, RONGFU · 2004 to 2022
$4.6M
NCI NIH HHS R01 CA101795NCI NIH HHS U54 CA210181
6 · The paper itself

Abstract

BECN2 (beclin 2) is a newly identified mammalian-specific macroautophagy/autophagy family member, and plays a critical role in the control of obesity and insulin sensitivity. However, its role in innate immune signaling and inflammation remains elusive. In our recent study, we show that BECN2 functions as a negative regulator in innate immune signaling and tumor development through non-canonical autophagy. Loss of

Indexed as

AutophagyNeoplasmsAnimalsAutophagy-Related ProteinsBeclin-1Immunity, InnateIntracellular Signaling Peptides and ProteinsMiceSignal TransductionAutophagy-Related ProteinsBeclin-1Becn2 protein, mouseIntracellular Signaling Peptides and ProteinsATG9ABECN2inflammation-associated cancerMAP3K3MAPK1/ERK2-MAPK3/ERK1 and NFKB signalingnon-canonical autophagy

Identifiers

PMID33121356
PMCPMC7751501
OpenAlexW3097524292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.