Evidence map›Paper›PMID 33121071›Full record

ReviewBiosensors2020

Biosensors for Detecting Lymphocytes and Immunoglobulins.

Pietro Salvo, Federico M Vivaldi, Andrea Bonini, Denise Biagini, Francesca G Bellagambi, Filippo M Miliani, Fabio Di Francesco, Tommaso Lomonaco

Abstract readReview
In one paragraph

Review in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. CD4Sensors (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pietro SalvoInstitute of Clinical Physiology, National Council of Research, Via Moruzzi 1, 56124 Pisa, Italy.
Federico M VivaldiInstitute of Clinical Physiology, National Council of Research, Via Moruzzi 1, 56124 Pisa, Italy.
Andrea BoniniDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.
Denise BiaginiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.
Francesca G BellagambiInstitut des Sciences Analytiques, UMR 5280, Université Lyon 1, 5, rue de la Doua, 69100 Villeurbanne, France.
Filippo M MilianiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0002-6320-1286
Fabio Di FrancescoDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0002-9285-1595
Tommaso LomonacoDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0002-1822-7399

Funding

Horizon 2020 Framework Programme 768686
6 · The paper itself

Abstract

Lymphocytes (B, T and natural killer cells) and immunoglobulins are essential for the adaptive immune response against external pathogens. Flow cytometry and enzyme-linked immunosorbent (ELISA) kits are the gold standards to detect immunoglobulins, B cells and T cells, whereas the impedance measurement is the most used technique for natural killer cells. For point-of-care, fast and low-cost devices, biosensors could be suitable for the reliable, stable and reproducible detection of immunoglobulins and lymphocytes. In the literature, such biosensors are commonly fabricated using antibodies, aptamers, proteins and nanomaterials, whereas electrochemical, optical and piezoelectric techniques are used for detection. This review describes how these measurement techniques and transducers can be used to fabricate biosensors for detecting lymphocytes and the total content of immunoglobulins. The various methods and configurations are reported, along with the advantages and current limitations.

Indexed as

Biosensing TechniquesLymphocytesAntibodiesAptamers, NucleotideElectrochemical TechniquesHumansImmunoglobulinsNanostructuresAntibodiesAptamers, NucleotideImmunoglobulinsaptasensorsB cellsbiosensorsimmunoglobulinsimmunosensorslymphocytesnatural killer cellsT cells

Identifiers

PMID33121071
PMCPMC7694141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.