ReviewMicromachines2020
Microneedles: Characteristics, Materials, Production Methods and Commercial Development.
Review in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05078463 (Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Innovations in Cannabis Delivery Systems: A Patent Review (2012-2024).Mini reviews in medicinal chemistry · 2025Pooled it
- Advancements and challenges in ophthalmic microneedles to treat eye diseases.Drug delivery · 2026Review
- Enhanced skin delivery of biomacromolecules using hollow sponge spicules.Bioengineering & translational medicine · 2026Article
- Design and Development of a Bioink for Fabricating Crosslinked Hydrogel Microneedles via 3D Printing for Transdermal Delivery of Estradiol Nanoparticles.Pharmaceutics · 2026Article
- Biomimetic Material Selection for Therapeutic Microneedles: An Analytic Hierarchy Process-Based Multi-Criteria Evaluation.Polymers · 2026Article
- Review
- Emerging and Prospective Engineering Technologies Enabling Microneedle Based Vaccine Therapeutics.AAPS PharmSciTech · 2026Review
- Article
- Advances in microneedle Technology for Treatment of retinal degenerative diseases: a narrative review.Biomedical microdevices · 2026Review
- Research Progress of Microneedles in Vaccine Delivery.Current medicinal chemistry · 2026Review
- Evolution of 3D-Printed Microneedles toward Closed-Loop Theranostic Platforms.Research (Washington, D.C.) · 2026Review
- Harnessing Polymeric Dissolvable Microneedles: Precision Delivery of Therapeutics for Oral Ulcers.ACS omega · 2025Review
- 3D necroprinting: Leveraging biotic material as the nozzle for 3D printing.Science advances · 2025Article
- Fabrication of bergapten loaded microneedle patch and assessment of its anti-arthritic potential against complete Freund's adjuvant induced arthritis in Wistar rat.Inflammopharmacology · 2025Article
- Engineering microneedles for biosensing and drug delivery.Bioactive materials · 2025Review
- Electrochemical Microneedles for Real-Time Monitoring in Interstitial Fluid: Emerging Technologies and Future Directions.Biosensors · 2025Review
- Development and in vitro tuning of empagliflozin-containing dissolvable microneedle patch for enhanced transdermal delivery.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Fabrication of porous polymeric microneedles: a concise overview.RSC advances · 2025Review
- Microneedles for Melanoma Therapy: Exploring Opportunities and Challenges.Pharmaceutics · 2025Review
- Use of a Silicon Microneedle Chip-Based Device for the Extraction and Subsequent Analysis of Dermal Interstitial Fluid in Heart Failure Patients.Diagnostics (Basel, Switzerland) · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although transdermal drug delivery systems (DDS) offer numerous benefits for patients, including the avoidance of both gastric irritation and first-pass metabolism effect, as well as improved patient compliance, only a limited number of active pharmaceutical ingredients (APIs) can be delivered accordingly. Microneedles (MNs) represent one of the most promising concepts for effective transdermal drug delivery that penetrate the protective skin barrier in a minimally invasive and painless manner. The first MNs were produced in the 90s, and since then, this field has been continually evolving. Therefore, different manufacturing methods, not only for MNs but also MN molds, are introduced, which allows for the cost-effective production of MNs for drug and vaccine delivery and even diagnostic/monitoring purposes. The focus of this review is to give a brief overview of MN characteristics, material composition, as well as the production and commercial development of MN-based systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.