ArticleLife (Basel, Switzerland)2020
Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling.
Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Honey as a Natural Flavorful Product: A Comprehensive Review of Its Potential Biological Activities and Recent Studies.Food science & nutrition · 2026Review
- Utilizing High-Throughput Screening of dHL-60 Inflammatory Behaviors to Evaluate Honey-Derived Molecules' Potential as Immunomodulatory Biomaterial Additives.Journal of inflammation research · 2026Article
- Honey and cancer: from traditional medicine to modern adjuvant therapy.Frontiers in oncology · 2026Review
- Correlation between Honey Parameters and Wound Healing Properties: The Case of Piedmont (Italy) Samples.Current pharmaceutical biotechnology · 2025Article
- Honey Bioactive Molecules: There Is a World Beyond the Sugars.Biotech (Basel (Switzerland)) · 2024Review
- Understanding the Anticancer Properties of Honey.International journal of molecular sciences · 2024Review
- The Antioxidant Potential of Commercial Manuka Honey from New Zealand-Biochemical and Cellular Studies.Current issues in molecular biology · 2024Article
- Growth inhibitory effect ofJournal of advanced veterinary and animal research · 2024Article
- Quality of Commercially Available Manuka Honey Expressed by Pollen Composition, Diastase Activity, and Hydroxymethylfurfural Content.Foods (Basel, Switzerland) · 2023Article
- Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Leptospermum extract (QV0) suppresses pleural mesothelioma tumor growthFrontiers in oncology · 2023Article
- Effects of Sangju Honey on Oral Squamous Carcinoma Cells.Journal of cancer prevention · 2022Article
- Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation.Life (Basel, Switzerland) · 2022Article
- Multidisciplinary analysis of Italian Alpine wildflower honey reveals criticalities, diversity and value.Scientific reports · 2021Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Honey is a natural product with a long use in traditional medicine and is well recognized to regulate different biological events. It is an important source of various biological or pharmacological molecules and, therefore, there is a strong interest to explore their properties. Evidence is growing that honey may have the potential to be an anticancer agent acting through several mechanisms. Here we observed for the first time in a cancer cell line a possible mechanism through which honey could induce an alteration in the intracellular reactive oxygen species and homeostatic balance of intracellular calcium concentration leading to cell death by apoptosis. This mechanism seems to be enhanced by manuka honey's ability to maintain high H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.