Evidence map›Paper›PMID 33120961›Full record

ArticleMicroorganisms2020

Probiotics Treatment Improves Hippocampal Dependent Cognition in a Rodent Model of Parkinson's Disease.

Caroline Xie, Asheeta A Prasad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Gut-directed therapy in Parkinson's disease.Frontiers in pharmacology · 2024
    Review
  15. Review
  16. Article
  17. The gastrointestinal tract and Parkinson's disease.Frontiers in cellular and infection microbiology · 2023
    Review
  18. Article
  19. Probiotics and the Treatment of Parkinson's Disease: An Update.Cellular and molecular neurobiology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caroline XieSchool of Psychology, UNSW Sydney, Sydney NSW 2052, Australia.
Asheeta A PrasadSchool of Psychology, UNSW Sydney, Sydney NSW 2052, Australia.

Funding

National Health and Medical Research Council APP1160412
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurological disorder with motor dysfunction and a number of psychiatric symptoms. Symptoms such as anxiety and cognitive deficits emerge prior to motor symptoms and persist over time. There are limited treatments targeting PD psychiatric symptoms. Emerging studies reveal that the gut microbe is altered in PD patients. Here we assessed the effect of a probiotic treatment in a rat model of PD. We used the neurotoxin (6-hydroxydopamine, 6-OHDA) in a preclinical PD model to examine the impact of a probiotic treatment (

Indexed as

6-Hydroxydopamineanxietycognitionhippocampusnon-motor symptomsParkinson’s diseaseprobioticsrat

Identifiers

PMID33120961
PMCPMC7692862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.