Trial reportInternational journal of environmental research and public health2020
Multiple Cryotherapy Attenuates Oxi-Inflammatory Response Following Skeletal Muscle Injury.
Trial report in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Whole-body cryotherapy can reduce the inflammatory response in humans: a meta-analysis based on 11 randomized controlled trials.Scientific reports · 2025Pooled it
- Impact of different cryotherapy interventions on post-exercise acute delayed-onset muscle soreness, athletic performance, and inflammatory biomarkers: a systematic review and network meta-analysis.Frontiers in sports and active living · 2026Review
- Effects of a Cooling Vest on Core and Skin Temperatures Following a Soccer-Specific Exercise Protocol.Sports (Basel, Switzerland) · 2025Article
- Effects of thermal interventions on skeletal muscle adaptations and regeneration: perspectives on epigenetics: a narrative review.European journal of applied physiology · 2025Review
- Article
- The Effect of Physical Activity and Repeated Whole-Body Cryotherapy on the Expression of Modulators of the Inflammatory Response in Mononuclear Blood Cells among Young Men.Journal of clinical medicine · 2024Article
- Pre-exercise cryotherapy reduces myoglobin and creatine kinase levels after eccentric muscle stress in young women.Frontiers in physiology · 2024Article
- Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues.bioRxiv : the preprint server for biology · 2023Article
- Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women.Healthcare (Basel, Switzerland) · 2022Article
- Lactoferrin Deficiency Impairs Proliferation of Satellite Cells via Downregulating the ERK1/2 Signaling Pathway.International journal of molecular sciences · 2022Article
- Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers.Antioxidants (Basel, Switzerland) · 2022Article
- The Effect of Repetitive Whole Body Cryotherapy Treatment on Adaptations to a Strength and Endurance Training Programme in Physically Active Males.Frontiers in sports and active living · 2022Article
- Cryostimulation for Post-exercise Recovery in Athletes: A Consensus and Position Paper.Frontiers in sports and active living · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oxi-inflammatory response is part of the natural process mobilizing leukocytes and satellite cells that contribute to clearance and regeneration of damaged muscle tissue. In sports medicine, a number of post-injury recovery strategies, such as whole-body cryotherapy (WBC), are used to improve skeletal muscle regeneration often without scientific evidence of their benefits. The study was designed to assess the impact of WBC on circulating mediators of skeletal muscle regeneration. Twenty elite athletes were randomized to WBC group (3-min exposure to -120 °C, twice a day for 7 days) and control group. Blood samples were collected before the first WBC session and 1 day after the last cryotherapy exposure. WBC did not affect the indirect markers of muscle damage but significantly reduced the generation of reactive oxygen and nitrogen species (H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.