ArticleChildren (Basel, Switzerland)2020
Nucleated Red Blood Cells: Could They Be Indicator Markers of Illness Severity for Neonatal Intensive Care Unit Patients?
Article in Children (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Nucleated red blood cells explain most of the association between DNA methylation and gestational age.Communications biology · 2023Article
- Frequency of Nucleated Red Blood Cells in the Peripheral Blood of ICU-Admitted Patients.Cureus · 2023Article
- New parameters on prediction of severity of transient tachypnea of the newborn.Turkish journal of medical sciences · 2022Article
- Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy.Stem cells international · 2022Review
- Comparison of the Percentage of Umbilical Cord Nucleated Red Blood Cells in Preterm Neonates during Vaginal Delivery and Emergency Cesarean Section.Iranian journal of nursing and midwifery researchArticle
- Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs.Journal of veterinary internal medicineArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to assess whether nucleated red blood cells (NRBCs) count could serve as a diagnostic and prognostic biomarker for morbidity and mortality in critically ill neonates.
methodsThe association between NRBCs count and neonatal morbidity and mortality was evaluated in an observational cohort of critically ill neonates hospitalized in our neonatal intensive care unit over a period of 69 months. The discriminative ability of NRBCs count as diagnostic and prognostic biomarkers was evaluated by performing the Receiver Operating Characteristics (ROC) curve analysis.
resultsAmong 467 critically ill neonates included in the study, 45 (9.6%) of them experienced in-hospital mortality. No statistically significant difference was found with regards to NRBCs count between survivors and non-survivors, although the median value for NRBCs was sometimes higher for non-survivors. ROC curve analysis showed that NRBCs is a good discriminator marker for the diagnosis of perinatal hypoxia in neonates with area under the curve (AUC) [AUC 0.710; 95% confidence interval (CI), 0.660-0.759] and predominantly in preterm neonates (AUC 0.921 (95% CI, 0.0849-0.0993)) by using a cut-off value of ≥11.2%, with 80% sensitivity and 88.7% specificity. NRBCs also revealed significant prognostic power for mortality in septic neonates (AUC 0.760 (95% CI, 0.631-0.888)) and especially in preterms with sepsis (AUC 0.816 (95% CI, 0.681-0.951)), with cut-off value ≥ 1%, resulting in 81.6% sensitivity and 78.1% specificity.
conclusionNRBCs count may be included among the early diagnostic and prognostic markers for sick neonates.
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