ArticleNanomaterials (Basel, Switzerland)2020
Bilayered Fibrin-Based Electrospun-Sprayed Scaffold Loaded with Platelet Lysate Enhances Wound Healing in a Diabetic Mouse Model.
Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Platelet concentrates integrated with tissue engineering scaffolds: a promising approach for wound healing application.Journal of nanobiotechnology · 2026Review
- Hybrid Nanofibers for Multimodal Accelerated Wound Healing.Advanced healthcare materials · 2026Article
- Interpenetrating gelatin/sodium alginate hydrogel with controlled PRP lysate delivery for accelerating diabetic wound healing with reduced scarring.RSC advances · 2026Article
- Multimodal Bioactive Approaches in Smart Dressings for Diabetic Foot Ulcers.International journal of nanomedicine · 2026Review
- Platelet Lysate-Based Biomaterials for Regenerative Tissue Engineering: A Comprehensive Review.International journal of nanomedicine · 2026Review
- Blood derivatives as monotherapy and combination therapy: A promising strategy for wound healing.Regenerative therapy · 2025Review
- Molecular Insights into the Superiority of Platelet Lysate over FBS for hASC Expansion and Wound Healing.Cells · 2025Article
- Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer.Journal of clinical medicine · 2024Article
- Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications.International journal of molecular sciences · 2024Review
- Review
- Therapeutic Efficacy of Polymeric Biomaterials in Treating Diabetic Wounds-An Upcoming Wound Healing Technology.Polymers · 2023Review
- Emerging Antimicrobial and Immunomodulatory Fiber-Based Scaffolding Systems for Treating Diabetic Foot Ulcers.Pharmaceutics · 2023Review
- PLCL/PCL Dressings with Platelet Lysate and Growth Factors Embedded in Fibrin for Chronic Wound Regeneration.International journal of nanomedicine · 2023Article
- Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.Cell proliferation · 2022Article
- Plasminogen-Loaded Fibrin Scaffold as Drug Delivery System for Wound Healing Applications.Pharmaceutics · 2022Article
- Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds.BioMed research international · 2022Review
- Application of Electrospun Nanofiber Membrane in the Treatment of Diabetic Wounds.Pharmaceutics · 2021Review
- Biomaterials Tailoring at the Nanoscale for Tissue Engineering and Advanced Therapies.Nanomaterials (Basel, Switzerland) · 2021Article
- Electrospun and co-electrospun biopolymer nanofibers for skin wounds on diabetic patients: an overview.RSC advances · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The present study examined the effects of a bilayered fibrin/poly(ether)urethane scaffold loaded with platelet lysate by a combination of electrospinning and spray, phase-inversion method for wound healing. In particular, the poly(ether)urethane layer was obtained using by a spray phase-inversion method and the fibrin fibers network were loaded with platelet lysate by electrospinning. The kinetics release and the bioactivity of growth factors released from platelet lysate-scaffold were investigated by ELISA and cell proliferation test using mouse fibroblasts, respectively. The in-vitro experiments demonstrated that a bilayered fibrin/poly(ether)urethane scaffold loaded with platelet lysate provides a sustained release of bioactive platelet-derived growth factors. The effect of a bilayered fibrin/poly(ether)urethane scaffold loaded with platelet lysate on wound healing in diabetic mouse (db/db) was also investigated. The application of the scaffold on full-thickness skin wounds significantly accelerated wound closure at day 14 post-surgery when compared to scaffold without platelet lysates or commercially available polyurethane film, and at the same level of growth factor-loaded scaffold. Histological analysis demonstrated an increased re-epithelialization and collagen deposition in platelet lysate and growth factor loaded scaffolds. The ability of bilayered fibrin/poly(ether)urethane scaffold loaded with platelet lysate to promote in-vivo wound healing suggests its usefulness in clinical treatment of diabetic ulcers.
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Registered trials
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