ArticleAntioxidants (Basel, Switzerland)2020
Parallel Molecular Evolution of Catalases and Superoxide Dismutases-Focus on Thermophilic Fungal Genomes.
Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Molecular and Physiological Insights into CAT- and SOD-Associated Redox Homeostasis Under Salt Stress inInternational journal of molecular sciences · 2026Article
- A Possible Involvement of Sialidase in the Cell Response of the Antarctic FungusLife (Basel, Switzerland) · 2025Article
- Goat Milk Exhibits a Higher Degree of Protein Oxidation and Aggregation than Cow Milk During Cold Storage.Foods (Basel, Switzerland) · 2025Article
- Targeted Screening ofFoods (Basel, Switzerland) · 2024Article
- Antioxidants as Protection against Reactive Oxidative Stress in Inflammatory Bowel Disease.Metabolites · 2023Review
- Stromal Ascorbate Peroxidase (Antioxidants (Basel, Switzerland) · 2023Article
- Ascorbate-Glutathione Cycle Genes Families in Euphorbiaceae: Characterization and Evolutionary Analysis.Biology · 2022Article
- A Systematic Review and Meta-Analysis on the Role of Nutraceuticals in the Management of Neuropathic Pain in In Vivo Studies.Antioxidants (Basel, Switzerland) · 2022Review
- Evolution of Heme Peroxygenases: Ancient Roots and Later Evolved Branches.Antioxidants (Basel, Switzerland) · 2022Article
- The Role of HAntioxidants (Basel, Switzerland) · 2022Article
- The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.Antioxidants (Basel, Switzerland) · 2021Review
- Enzymatic and Non-Enzymatic Molecules with Antioxidant Function.Antioxidants (Basel, Switzerland) · 2021Article
- Deletion of Superoxide Dismutase 1 Blunted Inflammatory Aortic Remodeling in Hypertensive Mice under Angiotensin II Infusion.Antioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
Catalases (CAT) and superoxide dismutases (SOD) represent two main groups of enzymatic antioxidants that are present in almost all aerobic organisms and even in certain anaerobes. They are closely interconnected in the catabolism of reactive oxygen species because one product of SOD reaction (hydrogen peroxide) is the main substrate of CAT reaction finally leading to harmless products (i.e., molecular oxygen and water). It is therefore interesting to compare the molecular evolution of corresponding gene families. We have used a phylogenomic approach to elucidate the evolutionary relationships among these two main enzymatic antioxidants with a focus on the genomes of thermophilic fungi. Distinct gene families coding for CuZnSODs, FeMnSODs, and heme catalases are very abundant in thermophilic Ascomycota. Here, the presented results demonstrate that whereas superoxide dismutase genes remained rather constant during long-term evolution, the total count of heme catalase genes was reduced in thermophilic fungi in comparison with their mesophilic counterparts. We demonstrate here, for the newly discovered ascomycetous genes coding for thermophilic superoxide dismutases and catalases (originating from our sequencing project), the expression patterns of corresponding mRNA transcripts and further analyze translated protein sequences. Our results provide important implications for the physiology of reactive oxygen species metabolism in eukaryotic cells at elevated temperatures.
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