Evidence map›Paper›PMID 33120824›Full record

Observational studyMedicine2020

Local functional connectivity of patients with acute and remitting multiple sclerosis: A Kendall's coefficient of concordance- and coherence-regional homogeneity study.

Yanyan Zhu, Muhua Huang, Yanlin Zhao, Yixiu Pei, Yao Wang, Lei Wang, Ting He, Fuqing Zhou, Xianjun Zeng

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Yanyan ZhuDepartment of Radiology, The First Affiliated Hospital, Nanchang University.ORCID 0000-0002-0119-464
Muhua HuangDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Yanlin ZhaoDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Yixiu PeiDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Yao WangDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Lei WangDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Ting HeDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Fuqing ZhouDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Xianjun ZengDepartment of Radiology, The First Affiliated Hospital, Nanchang University.
Apple (Israel) · ILNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using Kendall's coefficient of concordance (KCC-) and Coherence (Cohe-) regional homogeneity (ReHo) to explore the alterations of brain local functional connectivity in acute and remitting relapsing-remitting multiple sclerosis (RRMS), and its clinical relevance.18 acute RRMS, 26 remitting RRMS and 20 healthy controls received resting-state functional magnetic resonance imaging scanning. After data preprocessing and ReHo (KCC-ReHo and Cohe-ReHo) calculation, analysis of variance and followed post hoc analysis was used to compare the KCC-ReHo or Cohe ReHo maps across groups.After analysis of variance analysis, regions with significant among-group differences detected by the 2 ReHo analysis were overlapped, these overlapped regions located in the left superior frontal gyrus (SFG), right SFG, left cuneus and right middle occipital gyrus (P < .01, Gaussian random field theory correction). Followed post hoc tests showed that, compared with healthy controls,Both acute and remitting RRMS patients has disease-related brain dysfunction, interestingly, relative to remitting RRMS, the acute RRMS patients mobilized more brain regions involving visual information processing in an attempt to maintain functional stability. In addition, our results also provide a methodological consideration for future ReHo analysis.

Indexed as

AdultAnalysis of VarianceBrainBrain MappingCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMultiple Sclerosis, Relapsing-Remitting

Identifiers

PMID33120824
PMCPMC7581181
OpenAlexW3093721653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.