ArticleJournal of pediatric psychology2021
Early Life Adversity and Pubertal Timing: Implications for Cardiometabolic Health.
Article in Journal of pediatric psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The J shaped association of age at menarche and cardiovascular events: systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Puberty in Context: Accounting for Psychosocial Experiences in the Association Between Pubertal Timing, Sex/Gender, and Adolescent Depressive Symptoms in Canadian Youth.Depression and anxiety · 2026Article
- Family Functioning and Pubertal Maturation in Hispanic/Latino Children from the HCHS/SOL Youth.International journal of environmental research and public health · 2025Article
- Coming of age in war: Early life adversity, age at menarche, and mental health.Psychoneuroendocrinology · 2024Review
- COMMENTARY: Foundational social geroscience: Social stress, reproductive health, and lifecourse aging across mammals.Neuroscience and biobehavioral reviews · 2024Article
- Applying Life History Theory to Understand Earlier Onset of Puberty: An Adolescent Brain Cognitive Development Cohort Analysis.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024Article
- Childhood maltreatment and trajectories of cardiometabolic health across the reproductive life span among individuals with a first birth during the Coronary Artery Risk Development in Young Adults Study.Preventive medicine · 2024Article
- Mothers' prenatal distress accelerates adrenal pubertal development in daughters.Psychoneuroendocrinology · 2024Article
- Pubertal timing: A life course pathway linking early life risk to adulthood cardiometabolic health.PloS one · 2024Article
- Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11.Comprehensive psychoneuroendocrinology · 2023Article
- Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Article
- Age at Menarche, Growth Velocity, and Adiposity Indices in Italian Girls Aged 10 to 14.Children (Basel, Switzerland) · 2022Article
- Dimensions of childhood adversity differentially affect biological aging in major depression.Translational psychiatry · 2022Article
- Targeting Parenting Quality to Reduce Early Life Adversity Impacts on Lifespan Cardiometabolic Risk.Frontiers in psychology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo identify early life adversity (ELA) risk factors for earlier pubertal timing, itself a risk factor for poor cardiometabolic health, and to determine whether such ELA-related risk may be mediated by pre-pubertal body mass index (BMI).
methodsSubjects included 426 female participants in a prospective birth cohort study, the NICHD Study of Early Child Care and Youth Development. Survival analysis models were fit to examine ELA exposures, representing childhood socioeconomic status (SES), maternal sensitivity, mother-child attachment, and negative life events, along with child health indicators and covariates, in relation to pubertal timing outcomes, including age at menarche and ages at Tanner stage II for breast and pubic hair development.
resultsHigher childhood SES emerged as an independent predictor of older age at menarche, showing each one standard deviation increase in childhood SES corresponded to a 1.3% increase in age at menarche (factor change = 1.013; 1.003-1.022; p < .01), but did not predict breast or pubic hair development (ps > .05). In mediation analyses, indirect (mediated) effects of mother-child attachment on the pubertal timing outcomes, via pre-pubertal BMI, were all statistically significant (ps < .05).
conclusionsHigher childhood SES predicted directly, and secure (vs. insecure) mother-child attachment predicted indirectly (via pre-pubertal BMI), later pubertal timing, suggesting these factors may protect girls from earlier pubertal development. By extension, clinical implications are that intervention strategies designed to lessen ELA- and pre-pubertal obesity-related risk may be effective in remediating life course pathways linking ELA, accelerated pubertal development, and cardiometabolic risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.