Evidence map›Paper›PMID 33120086›Full record

ArticleNeurobiology of aging2021

Aging reduces the sensitivity to the reinforcing efficacy of morphine.

Angela R Bongiovanni, Kyle Peer, Rachel E Carpenter, Alexandra S Ellis, Michael R Duggan, Vinay Parikh, Mathieu E Wimmer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Impact of Age on Heroin Intravenous Self-Administration in Wistar Rats.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Rats chasing the dragon: A new heroin inhalation method.Journal of neuroscience methods · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Angela R BongiovanniDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA.
Kyle PeerDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA.
Rachel E CarpenterDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA.
Alexandra S EllisDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA.
Michael R DugganDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA.
Vinay ParikhDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA.
Mathieu E WimmerDepartment of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA. Electronic address: mathieu.wimmer@temple.edu.
Temple University · US

Funding

Unraveling Epigenetic Mechanisms Of Opioid Addiction Susceptibility Using Multigenerational Animal ModelsDP1DA046537 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI WIMMER, MATHIEU · 2018 to 2022
$2.5M
Mechanisms Underlying Learning Deficits Caused by Paternal Cocaine TakingK01DA039308 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WIMMER, MATHIEU · 2016 to 2020
$903k
Cholinergic overload and resilience to attentional capacities in agingR21AG046580 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI PARIKH, VINAY · 2015 to 2016
$421k
NIA NIH HHS R21 AG046580NIDA NIH HHS DP1 DA046537NIDA NIH HHS K01 DA039308
6 · The paper itself

Abstract

The US geriatric population is growing and using more opioids than ever before. The purpose of this study was to determine whether aging influenced the reinforcing efficacy of morphine in male and female rats using a rodent intravenous self-administration paradigm. Male and female aged (20-24 months) and young (2-4 months) Wistar rats were tested at 2 doses of morphine (0.75 mg/kg/infusion and 0.25 mg/kg/infusion). During 10 days of self-administration, aged rats took significantly less morphine than their younger counterparts at the 0.25 mg/kg/infusion dose. Aged males also earned significantly fewer infusions on a progressive ration reinforcement schedule at this dose, suggesting that the reinforcing efficacy of morphine is decreased for this group at this dose. These effects dissipated when a separate group of animals had access to the 0.75 mg/kg/infusion dose for both sexes. Our results indicate that morphine is less reinforcing at lower doses in aged male, but not female rats. This research has potential clinical implications for the chronic treatments involving opioids in aged individuals.

Indexed as

Reinforcement, PsychologyReinforcement ScheduleAgingAnimalsFemaleInfusions, IntravenousMaleMorphineRatsSelf AdministrationSex CharacteristicsMorphineAgingDrug sensitivityIntravenous self-administrationOpioid use disorderReinforcing efficacy

Identifiers

PMID33120086
PMCPMC7736565
OpenAlexW3089877879

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.