Evidence map›Paper›PMID 33120070›Full record

ArticleParkinsonism & related disorders2020

Essential tremor: Is the word "essential" really essential?

Abhishek Lenka, Elan D Louis

Abstract read
In one paragraph

Article in Parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diagnosis and Treatment of Essential Tremor.Continuum (Minneapolis, Minn.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Abhishek LenkaDepartment of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.
Elan D LouisDepartment of Neurology, University of Texas Southwestern, Dallas, TX, USA. Electronic address: elan.louis@utsouthwestern.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1M
PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATIONR01NS088257 · NINDS · YALE UNIVERSITY · PI FAUST, PHYLLIS L, LOUIS, ELAN D · 2015 to 2019
$3.3M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS086736NINDS NIH HHS R01 NS088257
6 · The paper itself

Abstract

Essential tremor (ET) is among the common movement disorders. A surge in research in recent years has considerably improved our understanding of disease etiology and pathogenesis, and its associated clinical phenomenology and natural history. With this progress have emerged a multitude of new questions and conundrums and newly proposed terminologies. Amidst these various related discussions, it is worth revisiting the essence of the nomenclature, "essential tremor", to assess how well it continues to fit the growing understanding of this entity. Here we revisit the historical underpinnings of the nomenclature, its accuracy, pitfalls of eliminating the word, and advantages of removing the word. There are two primary historical bases for using the word "essential": (i) idiopathic or unclear etiology, (ii) a unitary (single-featured) trait perceived as a constitutional feature. Numerous studies indicate that ET is neither truly idiopathic nor is fully isolated, making the use of "essential" technically incorrect. There are pitfalls and advantages of eliminating the term "essential" and both are succinctly described in this article. Yet in the absence of any flawless alternatives at present, we conclude that it is preferable for now to persist with "essential" tremor, thereby respecting the historical continuity of this one-and-a-half-century old nomenclature.

Indexed as

Essential TremorTerminology as TopicHumansEssentialEssential tremorMovement disordersTremor

Identifiers

PMID33120070
PMCPMC8341730

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.