Evidence map›Paper›PMID 33119814›Full record

ArticleEJNMMI research2020

Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson's disease: a longitudinal study.

Jingjie Ge, Min Wang, Wei Lin, Ping Wu, Yihui Guan, Huiwei Zhang, Zhemin Huang, Likun Yang, Chuantao Zuo, Jiehui Jiang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingjie GePET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
Min WangShanghai Institute for Advanced Communication and Data Science, Shanghai University, 99 Shangda Road, Shanghai, 200444, China.
Wei LinDepartment of Neurosurgery, 904 Hospital of PLA, Wuxi, China.
Ping WuPET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
Yihui GuanPET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
Huiwei ZhangPET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
Zhemin HuangPET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China.
Likun YangDepartment of Neurosurgery, 904 Hospital of PLA, Wuxi, China.
Chuantao ZuoPET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200235, China. zuochuantao2000@126.com.ORCID http://orcid.org/0000-0002-8856-7217
Jiehui JiangShanghai Institute for Advanced Communication and Data Science, Shanghai University, 99 Shangda Road, Shanghai, 200444, China. jiangjiehui@shu.edu.cn.ORCID http://orcid.org/0000-0003-4948-3683
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

National Key R&D Program of China 2018YFC1314700National Natural Science Foundation of China 81671239
6 · The paper itself

Abstract

backgroundWith the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson's disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with

methodsAge-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent

resultsThe PDRP expression was abnormally elevated in PD patients compared with HCs (P < 0.001). For DBS patients, a significant decrease in the Unified Parkinson's Disease Rating Scale (UPDRS, P = 0.001) and PDRP expression (P = 0.004) was observed 3 months after STN DBS treatment, while a rollback was observed in both UPDRS and PDRP expressions (both P < 0.01) 12 months after treatment. The changes in PDRP expression mediated by STN DBS were generally in line with UPDRS improvement. The graphical network analysis shows increased connections at 3 months and a return at 12 months confirmed by small-worldness coefficient.

conclusionsThe preliminary results demonstrate the potential of metabolic network expression as complimentary objective biomarker for the assessment and monitoring of STN DBS treatment in PD patients. Clinical Trial Registration ChiCTR-DOC-16008645.  http://www.chictr.org.cn/showproj.aspx?proj=13865 .

Indexed as

Deep brain stimulationGraph theoryParkinson’s diseasePD-related metabolic network patternSpatial covariance analysis

Identifiers

PMID33119814
PMCPMC7596139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.