Evidence map›Paper›PMID 33119734›Full record

ArticleNucleic acids research2021

DescribePROT: database of amino acid-level protein structure and function predictions.

Bi Zhao, Akila Katuwawala, Christopher J Oldfield, A Keith Dunker, Eshel Faraggi, Jörg Gsponer, Andrzej Kloczkowski, Nawar Malhis, Milot Mirdita, Zoran Obradovic and 4 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Prediction of Intrinsically Disordered Regions That Bind RNA with DisoRDPbind.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
  6. Comparative assessment of binding residue predictions in intrinsically disordered regions.Protein science : a publication of the Protein Society · 2025
    Article
  7. Article
  8. Article
  9. Accurate and Fast Prediction of Intrinsic Disorder Using flDPnn.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  10. Article
  11. Prediction of Intrinsic Disorder Functions with DEPICTER2.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bi ZhaoDepartment of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.
Akila KatuwawalaDepartment of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.
Christopher J OldfieldDepartment of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.
A Keith DunkerCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.
Eshel FaraggiBattelle Center for Mathematical Medicine at the Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Jörg GsponerMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Andrzej KloczkowskiBattelle Center for Mathematical Medicine at the Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Nawar MalhisMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Milot MirditaQuantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Zoran ObradovicDepartment of Computer and Information Sciences, Temple University, Philadelphia, PA, USA.
Johannes SödingQuantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Martin SteineggerSchool of Biological Sciences and Institute of Molecular Biology & Genetics, Seoul National University, Seoul, Republic of Korea.
Yaoqi ZhouInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.
Lukasz KurganDepartment of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.

Funding

Protein Sequence MatchingR01GM127701 · NIGMS · IOWA STATE UNIVERSITY · PI JERNIGAN, ROBERT L, KLOCZKOWSKI, ANDRZEJ · 2018 to 2021
$1.4M
NIGMS NIH HHS R01 GM127701
6 · The paper itself

Abstract

We present DescribePROT, the database of predicted amino acid-level descriptors of structure and function of proteins. DescribePROT delivers a comprehensive collection of 13 complementary descriptors predicted using 10 popular and accurate algorithms for 83 complete proteomes that cover key model organisms. The current version includes 7.8 billion predictions for close to 600 million amino acids in 1.4 million proteins. The descriptors encompass sequence conservation, position specific scoring matrix, secondary structure, solvent accessibility, intrinsic disorder, disordered linkers, signal peptides, MoRFs and interactions with proteins, DNA and RNAs. Users can search DescribePROT by the amino acid sequence and the UniProt accession number and entry name. The pre-computed results are made available instantaneously. The predictions can be accesses via an interactive graphical interface that allows simultaneous analysis of multiple descriptors and can be also downloaded in structured formats at the protein, proteome and whole database scale. The putative annotations included by DescriPROT are useful for a broad range of studies, including: investigations of protein function, applied projects focusing on therapeutics and diseases, and in the development of predictors for other protein sequence descriptors. Future releases will expand the coverage of DescribePROT. DescribePROT can be accessed at http://biomine.cs.vcu.edu/servers/DESCRIBEPROT/.

Indexed as

Databases, ProteinGenomeSoftwareAmino AcidsAmino Acid SequenceAnimalsArchaeaBacteriaBinding SitesConserved SequenceFungiHumansInternetPlantsProkaryotic CellsProtein BindingAmino AcidsProteinsProteome

Identifiers

PMID33119734
PMCPMC7778963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.