SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Dose-response Relation Deduced for Coronaviruses From Coronavirus Disease 2019, Severe Acute Respiratory Syndrome, and Middle East Respiratory Syndrome: Meta-analysis Results and its Application for Infection Risk Assessment of Aerosol Transmission.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04823351 (Randomized Controlled Trial to Compare Clinical Efficacy of Surgical and Filtering Facepiece 2 Masks for Care Home Workers Treating COVID-19 Patients), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial to Compare Clinical Efficacy of Surgical and Filtering Facepiece 2 Masks for Care Home Workers Treating COVID-19 Patients
Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
- Reframing Pandemic Preparedness: Why Positive-Pressure Exposure Control Merits Formal Public Health Evaluation.JMIR public health and surveillance · 2026Article
- Temporal contact patterns and the implications for predicting superspreaders and planning of targeted outbreak control.Journal of the Royal Society, Interface · 2024Article
- Detecting changes in generation and serial intervals under varying pathogen biology, contact patterns and outbreak response.PLoS computational biology · 2024Article
- Severity of respiratory tract infections depends on the infectious dose. Perspectives for the next pandemic.Frontiers in public health · 2024Article
- Article
- On-site airborne pathogen detection for infection risk mitigation.Chemical Society reviews · 2023Review
- Contamination and Transmission of SARS-CoV-2 Variants in Cold-Chain Food and Food Packaging.China CDC weekly · 2023Article
- Article
- A review on indoor airborne transmission of COVID-19- modelling and mitigation approaches.Journal of building engineering · 2023Review
- Modelling the impact of non-pharmaceutical interventions on workplace transmission of SARS-CoV-2 in the home-delivery sector.PloS one · 2023Article
- Pandemic management requires exposure science.Environment international · 2022Article
- Close contact behavior-based COVID-19 transmission and interventions in a subway system.Journal of hazardous materials · 2022Article
- Using thermodynamic equilibrium models to predict the effect of antiviral agents on infectivity: Theoretical application to SARS-CoV-2 and other viruses.Microbial risk analysis · 2022Article
- A population framework for predicting the proportion of people infected by the far-field airborne transmission of SARS-CoV-2 indoors.Building and environment · 2022Article
- Article
- SARS-CoV-2 and other airborne respiratory viruses in outdoor aerosols in three Swiss cities before and during the first wave of the COVID-19 pandemic.Environment international · 2022Article
- SARS-CoV-2 Droplet and Airborne Transmission Heterogeneity.Journal of clinical medicine · 2022Article
- Home quarantine: A numerical evaluation of SARS-CoV-2 spread in a single-family house.Indoor air · 2022Article
- Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events.Nature communications · 2022Article
- Respiratory pandemic and indoor aeraulics of classrooms.Building and environment · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA comprehensive understanding of the transmission routes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of great importance to effectively control the spread of coronavirus disease 2019 (COVID-19). However, the fundamental dose-response relation is missing for evaluation of the infection risk.
methodsWe developed a simple framework to integrate the a priori dose-response relation for SARS-CoV-2 based on mice experiments, the recent data on infection risk from a meta-analysis, and respiratory virus shedding in exhaled breath to shed light on the dose-response relation for humans. The aerosol transmission infection risk was evaluated based on the dose-response model for a typical indoor environment.
resultsThe developed dose-response relation is an exponential function with a constant k in the range of about 6.4 × 104 to 9.8 × 105 virus copies, which means that the infection risk caused by 1 virus copy in viral shedding is on the order of 10-6 to 10-5. The median infection risk via aerosol transmission with 1-hour exposure (10-6 to 10-4) was significantly lower than the risk caused by close contact (10-1) in a room with an area of 10 to 400 m2 with 1 infected individual in it and with a typical ventilation rate of 1 air change per hour.
conclusionsThe infection risk caused by aerosol transmission was significantly lower than the risk caused by close contact. It is still necessary to be cautious for the potential aerosol transmission risk in small rooms with prolonged exposure duration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.