ArticleJournal of psychiatry & neuroscience : JPN2021
Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach.
Article in Journal of psychiatry & neuroscience : JPN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 81 citations in OpenAlex.
- Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial.Translational psychiatry · 2025Trial
- Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders.Molecular psychiatry · 2026Article
- The 'UPIC' cohort: a nationwide prospective study of mental health among adolescents and young adults in Sweden - a study protocol.BMJ open · 2026Article
- Computational mechanisms of learning and forgetting differentiate affective and substance use disorders.Molecular psychiatry · 2026Article
- Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.bioRxiv : the preprint server for biology · 2026Article
- Human approach-avoidance conflict behaviour relates to transdiagnostic psychiatric symptom dimensions.Translational psychiatry · 2026Article
- Social approach-avoidance conflict: Behavioural, emotional, and neural correlates along a depression-social anxiety spectrum.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Attenuated learning rates for negative outcomes in substance use disorders: A replication and extension of prior longitudinal computational modeling results.Drug and alcohol dependence · 2026Article
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Agent-Based Behavioral Modeling of Human Associative Learning in a Complex Approach-Avoidance Conflict Task.Computational brain & behavior · 2025Article
- The Application ofInternational journal of molecular sciences · 2025Article
- Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans.PLoS biology · 2025Article
- Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict.PLoS biology · 2025Article
- Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders.Computational psychiatry (Cambridge, Mass.) · 2025Article
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cognitive Signatures of Depressive and Anhedonic Symptoms and Affective States Using Computational Modeling and Neurocognitive Testing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Updating Prospective Self-Efficacy Beliefs About Cardiac Interoception in Anorexia Nervosa: An Experimental and Computational Study.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Active learning impairments in substance use disorders when resolving the explore-exploit dilemma: A replication and extension of previous computational modeling results.Drug and alcohol dependence · 2023Article
- Interindividual Brain and Behavior Differences in Adaptation to Unexpected Uncertainty.Biology · 2023Article
- Decision-making for concurrent reward and threat is differentially modulated by trauma exposure and PTSD symptom severity.Behaviour research and therapy · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundImbalances in approach-avoidance conflict (AAC) decision-making (e.g., sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modelling to examine 2 factors that are often not distinguished in descriptive analyses of AAC: decision uncertainty and sensitivity to negative outcomes versus rewards (emotional conflict).
methodsA previously validated AAC task was completed by 478 participants, including healthy controls (
resultsThe model showed high accuracy (72%). As further validation, parameters correlated with reaction times and self-reported task motivations in expected directions. The emotional conflict parameter further correlated with self-reported anxiety during the task ( LIMITATIONS: This study was limited by heterogeneity of the clinical sample and an inability to examine learning.
conclusionThese results suggest that reduced confidence in how to act, rather than increased emotional conflict, may explain maladaptive approach-avoidance behaviours in people with psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.